Protein: FYCO1
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)

Gene: FYCO1
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9BQS8

Gene Ontology (top 5):
GO:0005764 - lysosome
GO:0005770 - late endosome
GO:0005776 - autophagosome
GO:0005794 - Golgi apparatus
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1410937

MLP3B
Microtubule-associated protein 1 light chain 3 beta

6

14

Small-scale

0.738

High

1410933

FYCO1
FYVE and coiled-coil domain-containing protein 1

2

19

Small-scale

0.737

High

1410941

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

4

14

Small-scale

0.683

High

610858

TCPA
T-complex protein 1 subunit alpha

3

9

High-throughput

0.667

High

1410951

DTNA
Dystrobrevin alpha

3

6

High-throughput

0.667

High

1410946

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

4

High-throughput

0.662

High

1410935

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

14

Small-scale

0.636

High

1389682

SGF29
SAGA-associated factor 29

4

1

High-throughput

0.630

High

749993

KINH
Kinesin-1 heavy chain

2

5

Small-scale

0.621

High

901527

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.618

High

902033

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.618

High

1329836

SIR6
NAD-dependent protein deacylase sirtuin-6

2

8

High-throughput

0.611

High

350971

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

3

1

High-throughput

0.609

High

821537

TCPZ
T-complex protein 1 subunit zeta

3

11

High-throughput

0.609

High

882122

TCPG
T-complex protein 1 subunit gamma

3

11

High-throughput

0.609

High

1007234

TCPB
T-complex protein 1 subunit beta

3

12

High-throughput

0.609

High

1248183

SAS6
Spindle assembly abnormal protein 6 homolog

3

18

High-throughput

0.609

High

1410940

CCD68
Coiled-coil domain-containing protein 68

3

5

High-throughput

0.609

High

1067656

EP300
Histone acetyltransferase p300

2

15

High-throughput

0.584

High

1363682

TCPW
T-complex protein 1 subunit zeta-2

2

14

High-throughput

0.558

High

1407536

TCPH
T-complex protein 1 subunit eta

2

11

High-throughput

0.558

High

64900

RCCD1
RCC1 domain-containing protein 1

2

7

High-throughput

0.549

High

1410515

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

262427

DTNB
Dystrobrevin beta

1

6

High-throughput

0.536

High

338535

SC24B
Protein transport protein Sec24B

1

3

High-throughput

0.536

High

696344

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.536

High

895010

EMD
Emerin

1

1

High-throughput

0.536

High

1149019

SC23B
Protein transport protein Sec23B

1

3

High-throughput

0.536

High

1154430

STK11
Serine/threonine-protein kinase STK11

1

3

High-throughput

0.536

High

1192959

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

7

High-throughput

0.536

High

1211340

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

1

High-throughput

0.536

High

1231872

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

3

High-throughput

0.536

High

1335951

ZBT44
Zinc finger and BTB domain-containing protein 44

1

2

High-throughput

0.536

High

1341255

CTCFL
Transcriptional repressor CTCFL

1

7

High-throughput

0.536

High

1398306

RN145
RING finger protein 145

1

5

High-throughput

0.536

High

1410942

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

12

High-throughput

0.536

High

1410945

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.536

High

328134

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

14

High-throughput

0.527

High

952320

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

14

High-throughput

0.527

High

1410938

KLC2
Kinesin light chain 2

1

5

Small-scale

0.527

High

1410939

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

14

High-throughput

0.527

High

246906

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.523

High

1396919

ANM6
Protein arginine N-methyltransferase 6

1

5

High-throughput

0.523

High

1410947

RRBP1
Ribosome-binding protein 1

1

18

High-throughput

0.515

High

167378

KLF11
Krueppel-like factor 11

1

7

High-throughput

0.515

High

274726

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.515

High

335499

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

422992

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

227259

KRT86
Keratin, type II cuticular Hb6

1

10

High-throughput

0.489

High

300826

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.489

High

386158

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.489

High

589537

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.489

High

685328

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.489

High

698361

MAP4
Microtubule-associated protein 4

1

18

High-throughput

0.489

High

769018

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.489

High

1017478

FOXK1
Forkhead box protein K1

1

6

High-throughput

0.489

High

1135584

K2C72
Keratin, type II cytoskeletal 72

1

11

High-throughput

0.489

High

1140137

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

5

High-throughput

0.489

High

1179025

S35G1
Solute carrier family 35 member G1

1

2

High-throughput

0.489

High

1311716

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

20

High-throughput

0.489

High

1313592

DDX60
Probable ATP-dependent RNA helicase DDX60

1

9

High-throughput

0.489

High

1314221

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

13

High-throughput

0.489

High

1410936

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.489

High

1410943

TF7L2
Transcription factor 7-like 2

1

11

High-throughput

0.489

High

1410950

KLDC2
Kelch domain-containing protein 2

1

15

High-throughput

0.489

High

401384

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

Small-scale

0.481

High

173285

XPO1
Exportin-1

1

8

High-throughput

0.479

High

242737

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

248768

PEPL
Periplakin

1

19

High-throughput

0.479

High

560497

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

562358

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

837815

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

4

High-throughput

0.479

High

839352

MTOR
Serine/threonine-protein kinase mTOR

1

9

High-throughput

0.479

High

1233451

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1255274

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1367132

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

1410944

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

High-throughput

0.479

High

1410948

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1410934

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.470

High

1017806

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.458

High

1339679

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1397963

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.445

High

353535

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

481371

HMGB1
High mobility group protein B1

1

12

High-throughput

0.437

High

1031520

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.437

High

1035873

KIF23
Kinesin-like protein KIF23

1

16

High-throughput

0.437

High

1106686

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.437

High

1135229

Q149M6
Exophilin 5

1

1

High-throughput

0.437

High

1360899

MUC16
Mucin-16

1

15

High-throughput

0.437

High

1382716

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.437

High

62588

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

1280172

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

High-throughput

0.426

High

81650

B5MDE0
Protein RFT1 homolog

1

1

High-throughput

0.407

High

117253

K7EKI8
Periplakin

1

17

High-throughput

0.407

High

837415

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

4

High-throughput

0.407

High

1337865

EXPH5
Exophilin-5

1

1

High-throughput

0.407

High

348260

DCMC
Malonyl-CoA decarboxylase, mitochondrial

3

0

High-throughput

0.347

High

1351641

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.328

High

1392335

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.318

High

260730

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

322457

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

1059128

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

1271333

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.279

Low

1308371

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

1316922

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

1387675

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1403187

AEDO
2-aminoethanethiol dioxygenase

1

0

High-throughput

0.279

Low

1410949

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.279

Low

1348194

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

190473

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025