HitPredict

Interactor 1: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Interactor 2: MSHR (Q01726)
Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R)
Gene: MC1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28947386
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 317
+	Hs
		827197 ARRB1_HUMAN (1-418): 0: 716: 100.00		MTR1L_HUMAN (11-313): 2.47e-60: 204: 17.19
+	Hs
		441649 ARRB1_HUMAN (1-418): 0: 716: 100.00		ADRB1_HUMAN (14-315): 6.23e-57: 192: 20.49
+	Hs
		802279 ARRB1_HUMAN (1-418): 0: 716: 100.00		GPR3_HUMAN (13-315): 7.65e-54: 180: 26.65
+	Hs
		428933 ARRB2_HUMAN (1-407): 0: 626: 76.15		ADRB2_HUMAN (1-316): 3.38e-65: 212: 20.89
+	Rn
		663954 ARRB2_RAT (1-407): 0: 616: 75.00		Q8VBU7_RAT (1-316): 1.5e-65: 213: 21.45
+	Hs
		656989 ARRB2_HUMAN (1-407): 0: 626: 76.15		5HT2A_HUMAN (2-317): 3.43e-59: 198: 16.35
+	Hs
		441648 ARRB2_HUMAN (1-407): 0: 626: 76.15		ADRB1_HUMAN (14-315): 6.23e-57: 192: 20.49
+	Hs
		685913 ARRB2_HUMAN (1-407): 0: 626: 76.15		MSHR_HUMAN (1-317): 1.34e-57: 190: 100.00
+	Hs
		685837 ARRB2_HUMAN (1-407): 0: 626: 76.15		GPR3_HUMAN (13-315): 7.65e-54: 180: 26.65