Protein: LEP
Leptin (Obese protein) (Obesity factor)

Gene: LEP
Organism: Homo sapiens
Interactions: 17
UniProt ID: P41159

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001525 - angiogenesis
GO:0001542 - ovulation from ovarian follicle
GO:0001666 - response to hypoxia
GO:0001890 - placenta development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

832470

LEPR
Leptin receptor

3

1

Small-scale

0.857

High

269157

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

224537

SIGL6
Sialic acid-binding Ig-like lectin 6

1

2

Small-scale

0.527

High

534741

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

551768

CO6A1

1

0

High-throughput

0.513

High

832471

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.513

High

832474

GLB1L
Beta-galactosidase-1-like protein

1

0

High-throughput

0.513

High

445142

S10A6
Protein S100-A6

1

1

Small-scale

0.501

High

682461

S100P
Protein S100-P

1

1

Small-scale

0.501

High

188588

SIGL5
Sialic acid-binding Ig-like lectin 5

1

2

Small-scale

0.481

High

628346

CD33
Myeloid cell surface antigen CD33

1

2

Small-scale

0.481

High

369633

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.480

High

832473

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

832472

CEBPD
CCAAT/enhancer-binding protein delta

1

2

Small-scale

0.437

High

771653

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

832475

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

832476

TOR3A
Torsin-3A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025