Protein: LEPR
Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)

Gene: LEPR
Organism: Homo sapiens
Interactions: 40
UniProt ID: P48357

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0004888 - transmembrane signaling receptor activity
GO:0004896 - cytokine receptor activity
GO:0005576 - extracellular region
GO:0005977 - glycogen metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

871476

BTNL8
Butyrophilin-like protein 8

3

6

High-throughput

0.861

High

832470

LEP
Leptin

3

1

Small-scale

0.857

High

871472

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

19

Small-scale

0.819

High

155922

SOCS3
Suppressor of cytokine signaling 3

2

20

Small-scale

0.768

High

871466

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.691

High

871484

TAFA4
Chemokine-like protein TAFA-4

2

5

High-throughput

0.628

High

295424

SPI2
Serpin I2

1

4

High-throughput

0.618

High

507668

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.618

High

871465

LEPR
Leptin receptor

1

19

Small-scale

0.618

High

871487

CDCP1
CUB domain-containing protein 1

2

0

High-throughput

0.602

High

253323

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.575

High

471736

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.575

High

871473

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

19

High-throughput

0.575

High

351669

SG1D1
Secretoglobin family 1D member 1

2

1

High-throughput

0.574

High

871470

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.553

High

871467

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

871479

D107A
Beta-defensin 107

1

0

High-throughput

0.513

High

871471

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.508

High

871485

NECD
Necdin

1

3

Small-scale

0.504

High

871482

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

871477

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.489

High

871480

TAFA2
Chemokine-like protein TAFA-2

1

5

High-throughput

0.489

High

871491

FBX2
F-box only protein 2

1

13

High-throughput

0.489

High

828185

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

Small-scale

0.470

High

871478

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.439

High

871486

RNF41
E3 ubiquitin-protein ligase NRDP1

1

10

Small-scale

0.439

High

255395

SNX2
Sorting nexin-2

1

4

Small-scale

0.437

High

329826

SNX4
Sorting nexin-4

1

4

Small-scale

0.437

High

871469

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

871475

SNX1
Sorting nexin-1

1

4

Small-scale

0.437

High

871490

FBX6
F-box only protein 6

1

13

High-throughput

0.437

High

871492

SNX6
Sorting nexin-6

1

4

Small-scale

0.437

High

871481

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

871483

S67A1
Solute carrier family 67 member A1

1

7

High-throughput

0.407

High

871468

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.318

High

183879

OBRG
Leptin receptor gene-related protein

1

0

Small-scale

0.292

High

871474

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.282

High

871488

AS3MT
Arsenite methyltransferase

1

0

High-throughput

0.279

Low

871489

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025