HitPredict

Interactor 1: COMP (P49747)
Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)
Gene: COMP

Interactor 2: ATS12 (P58397)
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)
Gene: ADAMTS12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	16611630, 18485748
Identification Methods	protease assay, anti tag coimmunoprecipitation
Interaction Type	protein cleavage, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0030199 - collagen fibril organization GO:0031012 - extracellular matrix
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 757 Hs			1 1594
+	Hs
		832889 COMP_HUMAN (1-757): 0: 552: 100.00		ATS7_HUMAN (47-1587): 0: 858: 42.42
+	Hs
		980468 NOTC2_HUMAN (6-530): 3.78e-23: 107: 13.98		ATS17_HUMAN (996-1581): 2.24e-47: 188: 17.34
+	Hs
		254219 SLIT1_HUMAN (282-489): 4.12e-13: 75.6: 15.91		ATL4_HUMAN (1186-1571): 5.15e-57: 218: 21.82
+	Hs
		612872 FBLN1_HUMAN (121-221): 3.7e-12: 72: 38.68		ATL4_HUMAN (1186-1571): 5.15e-57: 218: 21.82
+	Hs
		980561 NOTC2_HUMAN (6-530): 3.78e-23: 107: 13.98		ATS9_HUMAN (898-1591): 1.83e-32: 140: 15.12
+	Hs
		724378 FBN2_HUMAN (95-287): 8.74e-15: 80.9: 21.43		ATL5_HUMAN (542-815): 5.43e-40: 157: 36.33
+	Hs
		724345 FBN1_HUMAN (113-318): 1.85e-10: 67: 19.74		ATL5_HUMAN (542-815): 5.43e-40: 157: 36.33
+	Hs
		980469 NOTC2_HUMAN (6-530): 3.78e-23: 107: 13.98		ATS15_HUMAN (1425-1531): 3e-15: 83.5: 35.09
+	Hs
		980569 NOTC2_HUMAN (6-530): 3.78e-23: 107: 13.98		ATS1_HUMAN (528-996): 1.62e-11: 71.6: 12.81
+	Hs
		724382 FBN2_HUMAN (95-287): 8.74e-15: 80.9: 21.43		ATL1_HUMAN (740-944): 5.09e-17: 89.9: 15.39
+	Hs
		612877 FBLN1_HUMAN (121-221): 3.7e-12: 72: 38.68		ATL2_HUMAN (1315-1436): 1.55e-10: 68.2: 27.74