HitPredict

Interactor 1: VPS41 (P49754)
Vacuolar protein sorting-associated protein 41 homolog (S53)
Gene: VPS41

Interactor 2: TGFA1 (Q8WUH2)
Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
Gene: TGFBRAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Clathrin~Clathrin
Common GO terms	GO:0008333 - endosome to lysosome transport GO:0016020 - membrane GO:0034058 - endosomal vesicle fusion GO:0035542 - regulation of SNARE complex assembly
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 854 Hs			1 860
+	Hs
		833158 VPS41_HUMAN (1-854): 0: 960: 100.00		VPS39_HUMAN (21-854): 0: 549: 22.55
+	Hs
		833136 VPS41_HUMAN (1-854): 0: 960: 100.00		VPS41_HUMAN (28-854): 2.74e-119: 383: 12.94
+	Hs
		833172 VPS41_HUMAN (1-854): 0: 960: 100.00		VPS18_HUMAN (248-845): 2.73e-108: 357: 12.19
+	Mm
		1129052 VPS41_MOUSE (28-854): 0: 950: 97.34		VPS18_MOUSE (248-845): 3.13e-106: 351: 12.03
+	Hs
		833167 VPS41_HUMAN (1-854): 0: 960: 100.00		VPS11_HUMAN (23-854): 1.56e-92: 314: 12.50
+	Rn
		78212 D3ZVH6_RAT (28-764): 0: 810: 91.60		B5DFJ4_RAT (248-859): 3.29e-106: 351: 11.92
+	Rn
		88800 D3ZVH6_RAT (28-764): 0: 810: 91.60		D3ZVH6_RAT (28-792): 1.69e-99: 328: 13.52
+	Hs
		1260136 VPS18_HUMAN (281-827): 8.87e-114: 372: 13.32		TGFA1_HUMAN (1-860): 0: 662: 100.00
+	Hs
		1295095 VPS18_HUMAN (281-827): 8.87e-114: 372: 13.32		VPS39_HUMAN (21-854): 0: 549: 22.55
+	Mm
		1246836 VPS18_MOUSE (281-827): 3.11e-115: 376: 13.15		VPS39_MOUSE (21-846): 1.11e-180: 544: 22.07
+	Rn
		78213 B5DFJ4_RAT (281-827): 5.01e-115: 375: 13.15		E9PT04_RAT (34-846): 7.94e-179: 539: 22.47
+	Sc
		619694 VPS41_YEAST (28-790): 2.29e-179: 544: 23.72		VPS3_YEAST (28-800): 9.9e-79: 277: 14.25
+	Sc
		653807 VPS41_YEAST (28-790): 2.29e-179: 544: 23.72		PEP3_YEAST (252-853): 7.36e-75: 264: 12.93
+	Sc
		758426 VPS41_YEAST (28-790): 2.29e-179: 544: 23.72		VAM6_YEAST (431-850): 4.34e-66: 241: 19.78
+	Sc
		758406 VPS41_YEAST (28-790): 2.29e-179: 544: 23.72		VPS41_YEAST (296-817): 3.28e-51: 196: 12.68
+	Hs
		1329147 VPS18_HUMAN (281-827): 8.87e-114: 372: 13.32		VPS11_HUMAN (23-854): 1.56e-92: 314: 12.50
+	Sc
		619687 PEP3_YEAST (172-834): 9.16e-109: 357: 14.51		VPS3_YEAST (28-800): 9.9e-79: 277: 14.25