HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: ZCH18 (Q86VM9)
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)
Gene: ZC3H18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 953
+	Hs
		833765 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		834073 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		1201686 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		1201571 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		414977 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		833993 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		833803 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		MINT_HUMAN (8-923): 2.4e-20: 99.8: 10.24
+	Hs
		833836 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		833918 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		3286 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		A0A0S2Z4Z6_HUMAN (97-903): 3.62e-14: 79: 10.66
+	Hs
		833769 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		834148 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		1335031 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		834079 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		833716 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		PRB3_HUMAN (741-951): 2.04e-09: 62.5: 8.06
+	Hs
		625642 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		625528 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54
+	Hs
		1268608 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		1264773 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54
+	Ce
		246633 MBK2_CAEEL (145-487): 5.44e-111: 349: 27.93		O61201_CAEEL (110-953): 2.88e-10: 67: 11.66