Protein: ERR1
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)

Gene: ERR1, ESRRA
Organism: Homo sapiens
Interactions: 55
UniProt ID: P11474

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001650 - fibrillar center

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

543569

ERR3
Estrogen-related receptor gamma

7

19

Small-scale

0.959

High

543603

NCOA3
Nuclear receptor coactivator 3

4

20

Small-scale

0.882

High

395390

ESR1
Estrogen receptor

3

19

Small-scale

0.835

High

543577

NCOA1
Nuclear receptor coactivator 1

3

20

Small-scale

0.833

High

543597

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

9

20

Small-scale

0.756

High

343215

ERR2
Steroid hormone receptor ERR2

1

19

High-throughput

0.691

High

543564

TNNI2
Troponin I, fast skeletal muscle

3

3

High-throughput

0.654

High

543576

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.647

High

543559

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.621

High

543562

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.621

High

543565

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

20

High-throughput

0.621

High

543575

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

High-throughput

0.621

High

543588

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

15

Small-scale

0.611

High

543570

RNF4
E3 ubiquitin-protein ligase RNF4

2

5

High-throughput

0.606

High

543572

REL
Proto-oncogene c-Rel

2

20

High-throughput

0.606

High

543578

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.597

High

543563

NRIP1
Nuclear receptor-interacting protein 1

2

15

Small-scale

0.594

High

543584

PIAS4
E3 SUMO-protein ligase PIAS4

2

18

Small-scale

0.586

High

438070

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

543587

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.561

High

543583

FAM9A
Protein FAM9A

2

1

High-throughput

0.553

High

543566

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

543594

HDAC8
Histone deacetylase 8

1

20

Small-scale

0.536

High

216617

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.536

High

543595

PGES2
Prostaglandin E synthase 2

1

1

High-throughput

0.536

High

543558

ADHX
Alcohol dehydrogenase class-3

1

0

High-throughput

0.518

High

464776

SP1
Transcription factor Sp1

1

20

Small-scale

0.501

High

543580

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

20

Small-scale

0.501

High

543590

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.489

High

543592

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.489

High

543560

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

2

High-throughput

0.481

High

543561

FUS
RNA-binding protein FUS

1

20

High-throughput

0.481

High

543568

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.481

High

543573

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.481

High

543579

EXOS6
Exosome complex component MTR3

1

13

High-throughput

0.481

High

543586

PROX1
Prospero homeobox protein 1

1

2

High-throughput

0.481

High

543589

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

543593

LYST
Lysosomal-trafficking regulator

1

9

Small-scale

0.481

High

543598

NXF1
Nuclear RNA export factor 1

1

3

High-throughput

0.481

High

543601

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

20

High-throughput

0.481

High

128739

MEN1
Menin

1

7

High-throughput

0.479

High

240598

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.479

High

345305

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

413082

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

543567

SUMO3
Small ubiquitin-related modifier 3

1

10

Small-scale

0.479

High

543571

TFAP4
Transcription factor AP-4

1

3

Small-scale

0.479

High

543574

CUL3
Cullin-3

1

10

High-throughput

0.479

High

543581

LYRIC
Protein LYRIC

1

1

Small-scale

0.479

High

543582

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

20

Small-scale

0.479

High

543585

KDM2B
Lysine-specific demethylase 2B

1

15

Small-scale

0.479

High

543591

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

543599

BRPF3
Bromodomain and PHD finger-containing protein 3

1

14

High-throughput

0.479

High

543600

CHIP
E3 ubiquitin-protein ligase CHIP

1

14

Small-scale

0.479

High

543602

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.479

High

543596

PNRC2
Proline-rich nuclear receptor coactivator 2

1

15

Small-scale

0.457

High


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Last updated: 11Aug2025