HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	25416956, 34133714
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 471
+	Hs
		833888 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Dm
		834210 DOA_DROME (8-494): 4.91e-114: 357: 51.83		CPSF6_DROME (13-409): 3.19e-41: 157: 29.78
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		834033 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516362 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		1031320 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		516508 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36