HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 261
+	Hs
		833788 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRS12_HUMAN (1-261): 8.09e-38: 135: 100.00
+	Hs
		266941 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		266940 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		834087 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRS12_HUMAN (1-261): 8.09e-38: 135: 100.00
+	Hs
		266942 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		267075 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		833865 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		833711 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		834022 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		834033 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		833887 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		833742 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		267037 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		516362 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		834053 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	At
		847172 AFC2_ARATH (136-483): 6.83e-118: 355: 47.35		SRC33_ARATH (5-254): 1.33e-21: 93: 29.20
+	Hs
		625466 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Dm
		834186 DOA_DROME (8-494): 4.91e-114: 357: 51.83		Q9V3T8_DROME (11-87): 1.48e-10: 60.8: 50.65