Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 9452432, 25959826, 12535650, 15474363, 12297508, 22036569
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Presenilin~Presenilin
Common GO terms GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001568 - blood vessel development
and 128 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 467
Hs

1 467
+ Mm
+ Rn
+ Hs
+ Mm
+ Hs
+ Dm
+ Ce

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Last updated: 15 Jul 2024