HitPredict

Interactor 1: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Interactor 2: APH1A (Q96BI3)
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
Gene: APH1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.961

The method score is based on:

Property Details
Experiments 17911105, 18667537, 14572442, 12471034, 12297508, 15474363, 25394380
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Aph-1~Presenilin
Common GO terms GO:0000139 - Golgi membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
and 12 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 467
Hs

1 265
+ Mm
+ Rn
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Dm
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024