HitPredict

Interactor 1: PSN1 (P49769)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: Psen1

Interactor 2: PEN2 (Q9CQR7)
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
Gene: Psenen

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

The method score is based on:

Property	Details
Experiments	15474363, 16449386, 16641999, 22036569
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PEN-2~Presenilin
Common GO terms	GO:0000139 - Golgi membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 11 others more... GO:0006509 - membrane protein ectodomain proteolysis GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0016020 - membrane GO:0016485 - protein processing GO:0034205 - amyloid-beta formation GO:0042734 - presynaptic membrane GO:0042982 - amyloid precursor protein metabolic process GO:0042987 - amyloid precursor protein catabolic process GO:0043085 - positive regulation of catalytic activity GO:0070765 - gamma-secretase complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	467
Mm

1	101

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024