HitPredict

Interactor 1: SERPH (P50454)
Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)
Gene: SERPINH1

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005518 - collagen binding GO:0030199 - collagen fibril organization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 855
+	Hs
		507912 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		384501 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		609214 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		FGFR3_HUMAN (485-851): 5.88e-101: 333: 31.28
+	Hs
		839599 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		384377 SPB6_HUMAN (43-409): 4.91e-150: 431: 29.52		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		397004 PAI2_HUMAN (43-409): 3.39e-150: 433: 25.36		YES_HUMAN (556-850): 2.32e-97: 316: 34.58
+	Hs
		433287 SPB4_HUMAN (41-409): 2.8e-150: 433: 26.02		YES_HUMAN (556-850): 2.32e-97: 316: 34.58
+	Rn
		403561 SPA3K_RAT (5-409): 3.49e-160: 459: 23.97		INSR_RAT (511-849): 4.34e-54: 206: 37.46
+	Hs
		435588 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		839572 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		ROR1_HUMAN (556-849): 2.13e-58: 217: 39.87
+	Hs
		411337 SERPH_HUMAN (1-418): 7.1e-152: 438: 100.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		968345 SPB13_HUMAN (42-409): 5.1e-148: 427: 25.06		ROR1_HUMAN (556-849): 2.13e-58: 217: 39.87