Protein: HUTH
Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)

Gene: HUTH, HAL
Organism: Homo sapiens
Interactions: 174
UniProt ID: P42357

Gene Ontology (top 5):
GO:0004397 - histidine ammonia-lyase activity
GO:0005829 - cytosol
GO:0006548 - L-histidine catabolic process
GO:0019556 - L-histidine catabolic process to glutamate and formamide
GO:0019557 - L-histidine catabolic process to glutamate and formate

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839629

RAB9B
Ras-related protein Rab-9B

3

1

High-throughput

0.667

High

839536

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

839552

GPR18
N-arachidonyl glycine receptor

3

1

High-throughput

0.609

High

839610

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

839553

TNIP1
TNFAIP3-interacting protein 1

3

0

High-throughput

0.606

High

391581

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

839550

CUL1
Cullin-1

2

0

High-throughput

0.602

High

839607

DOC10
Dedicator of cytokinesis protein 10

2

0

High-throughput

0.602

High

839611

HEXI2
Protein HEXIM2

2

0

High-throughput

0.602

High

839612

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

839625

PKHA3
Pleckstrin homology domain-containing family A member 3

2

0

High-throughput

0.602

High

839580

AROS
Active regulator of SIRT1

2

0

High-throughput

0.585

High

839582

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

2

0

High-throughput

0.585

High

839569

KCD16
BTB/POZ domain-containing protein KCTD16

2

1

High-throughput

0.574

High

839537

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.547

High

533254

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.536

High

839531

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

1

High-throughput

0.536

High

839572

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.536

High

839635

DTL
Denticleless protein homolog

1

1

High-throughput

0.536

High

185170

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.513

High

251720

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

602756

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

633618

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.513

High

639203

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

High-throughput

0.513

High

649781

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.513

High

722773

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

839533

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

839535

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

839538

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

839540

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

839542

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

839543

ENL
Protein ENL

1

0

High-throughput

0.513

High

839545

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.513

High

839554

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.513

High

839557

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

839563

VWA3B
von Willebrand factor A domain-containing protein 3B

1

0

High-throughput

0.513

High

839589

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

839601

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.513

High

839615

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

839632

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

839648

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

325299

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

335311

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

1

High-throughput

0.489

High

839588

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.489

High

839618

S39A3
Zinc transporter ZIP3

1

1

High-throughput

0.489

High

839626

HES4
Transcription factor HES-4

1

1

High-throughput

0.489

High

373818

RASN
GTPase NRas

1

1

High-throughput

0.479

High

839541

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

348993

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

400433

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

413350

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

484973

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

536672

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

557920

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

839527

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

839528

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

839539

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

839551

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

839561

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.458

High

839598

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

839630

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

224949

TLX3
T-cell leukemia homeobox protein 3

1

1

High-throughput

0.457

High

226519

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.457

High

572908

INSRR
Insulin receptor-related protein

1

1

High-throughput

0.457

High

710677

EPHA8
Ephrin type-A receptor 8

1

1

High-throughput

0.457

High

832500

ETV3
ETS translocation variant 3

1

1

High-throughput

0.457

High

837023

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.457

High

839530

LHX2
LIM/homeobox protein Lhx2

1

2

High-throughput

0.457

High

839585

LMTK2
Serine/threonine-protein kinase LMTK2

1

2

High-throughput

0.457

High

839603

LHX4
LIM/homeobox protein Lhx4

1

2

High-throughput

0.457

High

839638

LHX3
LIM/homeobox protein Lhx3

1

2

High-throughput

0.457

High

650529

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.445

High

839433

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

839617

KLDC3
Kelch domain-containing protein 3

1

1

High-throughput

0.445

High

663846

FCAR
Immunoglobulin alpha Fc receptor

1

1

High-throughput

0.437

High

833895

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

Small-scale

0.437

High

839534

UCP2
Dicarboxylate carrier SLC25A8

1

1

High-throughput

0.437

High

839562

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

276569

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.426

High

839532

T2AG
Transcription initiation factor IIA subunit 2

1

0

High-throughput

0.426

High

839548

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.426

High

839565

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

839568

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

839573

FBX50
F-box only protein 50

1

0

High-throughput

0.426

High

839595

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.426

High

839604

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.426

High

839621

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.426

High

839640

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

839592

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

839649

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

1

High-throughput

0.407

High

839650

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

2

High-throughput

0.407

High

839529

VEGFB
Vascular endothelial growth factor B

3

0

High-throughput

0.347

High

839555

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

0

High-throughput

0.347

High

839574

DPPA4
Developmental pluripotency-associated protein 4

3

0

High-throughput

0.347

High

839558

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.328

High

839559

CCD27
Coiled-coil domain-containing protein 27

2

0

High-throughput

0.328

High

839576

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

839633

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

839646

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

600538

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

0

High-throughput

0.318

High

839593

UBAC2
Ubiquitin-associated domain-containing protein 2

2

0

High-throughput

0.318

High

839642

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.318

High

213397

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

0

High-throughput

0.288

High

194462

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

231209

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

254865

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

282684

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

351666

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.279

Low

420246

IFNA4
Interferon alpha-4

1

0

High-throughput

0.279

Low

552155

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.279

Low

618373

TSN8
Tetraspanin-8

1

0

High-throughput

0.279

Low

733300

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

839547

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.279

Low

839549

ZN154
Zinc finger protein 154

1

0

High-throughput

0.279

Low

839560

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

839564

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

839566

CJ120
Uncharacterized protein C10orf120

1

0

High-throughput

0.279

Low

839567

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

839575

APTX
Aprataxin

1

0

High-throughput

0.279

Low

839577

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

839578

BPHL
Serine hydrolase BPHL

1

0

High-throughput

0.279

Low

839581

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.279

Low

839583

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

839586

UBAD2
UBA-like domain-containing protein 2

1

0

High-throughput

0.279

Low

839590

FGRL1
Fibroblast growth factor receptor-like 1

1

0

High-throughput

0.279

Low

839594

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.279

Low

839596

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.279

Low

839600

ITLN2
Intelectin-2

1

0

High-throughput

0.279

Low

839602

WNT8B
Protein Wnt-8b

1

0

High-throughput

0.279

Low

839605

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

839606

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.279

Low

839608

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

839613

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

839616

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

839619

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

839623

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

839624

CLK4
Dual specificity protein kinase CLK4

1

0

High-throughput

0.279

Low

839627

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

839631

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

839634

TLR7
Toll-like receptor 7

1

0

High-throughput

0.279

Low

839637

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

839639

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

839645

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

839622

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.269

Low

839546

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.261

Low

839597

SP7
Transcription factor Sp7

1

0

High-throughput

0.261

Low

293331

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

640795

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.249

Low

698458

CALX
Calnexin

1

0

High-throughput

0.249

Low

820603

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

839636

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

839647

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

238769

SSX4
Protein SSX4

1

0

High-throughput

0.232

Low

244937

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

261117

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

276209

LRRN2
Leucine-rich repeat neuronal protein 2

1

0

High-throughput

0.232

Low

326673

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.232

Low

547982

PSPC
Surfactant protein C

1

0

High-throughput

0.232

Low

839544

COAA1

1

0

High-throughput

0.232

Low

839556

CYTM
Cystatin-M

1

0

High-throughput

0.232

Low

839570

KLH10
Kelch-like protein 10

1

0

High-throughput

0.232

Low

839571

SBSN
Suprabasin

1

0

High-throughput

0.232

Low

839579

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low

839584

SPA12
Serpin A12

1

0

High-throughput

0.232

Low

839587

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.232

Low

839591

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.232

Low

839599

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low

839609

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.232

Low

839614

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

839620

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low

839628

S10AE
Protein S100-A14

1

0

High-throughput

0.232

Low

839641

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.232

Low

839643

T53G5
TP53-target gene 5 protein

1

0

High-throughput

0.232

Low

839644

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025