Protein: SPD5
Spindle-defective protein 5

Gene: SPD5, spd-5
Organism: Caenorhabditis elegans
Interactions: 132
UniProt ID: P91349

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0007052 - mitotic spindle organization
GO:0007098 - centrosome cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

954360

SPD5
Spindle-defective protein 5

5

17

Small-scale

0.711

High

711408

PLK1
Serine/threonine-protein kinase plk-1

4

3

Small-scale

0.701

High

954361

SPD2
Spindle-defective protein 2

5

0

Small-scale

0.677

High

137510

P2R31
Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1

2

1

Small-scale

0.611

High

954422

NLK
Serine/threonine kinase NLK

2

14

High-throughput

0.594

High

107014

ZYG9
Zygote defective protein 9

2

3

Small-scale

0.584

High

106141

G5EDL3
Aurora kinase

2

16

High-throughput

0.576

High

954199

CSN5
COP9 signalosome complex subunit 5

2

3

High-throughput

0.576

High

107875

RSA2
Regulator of spindle assembly protein 2

2

0

Small-scale

0.541

High

220113

NH111
Nuclear hormone receptor family member nhr-111

1

17

High-throughput

0.494

High

106041

G5EDE7
TPX2 domain-containing protein

1

0

Small-scale

0.480

High

104644

G5EC10
Galectin

1

5

High-throughput

0.479

High

105519

G5ECV9
10-formyltetrahydrofolate dehydrogenase

1

3

High-throughput

0.479

High

137726

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

183858

O16366
CEntrosomal Protein

1

5

High-throughput

0.479

High

218705

O44490
ELKS/RAB6-interacting/CAST family member 2

1

17

High-throughput

0.479

High

220403

CPL1
Cathepsin L-like

1

5

High-throughput

0.479

High

503309

HSP6
Heat shock protein hsp-6

1

8

High-throughput

0.479

High

697545

CLAS2
Protein CLASP-2

1

3

High-throughput

0.479

High

712569

GLH1
ATP-dependent RNA helicase glh-1

1

3

High-throughput

0.479

High

879052

SUMO
Small ubiquitin-related modifier

1

1

High-throughput

0.479

High

954376

IFB2
Intermediate filament protein ifb-2

1

3

High-throughput

0.479

High

954380

SIP1
Stress-induced protein 1

1

11

High-throughput

0.479

High

954384

IFC2
Intermediate filament protein ifc-2

1

5

High-throughput

0.479

High

954387

ANKHM
Ankyrin repeat and KH domain-containing protein mask-1

1

6

High-throughput

0.479

High

954388

Q22167
EF-hand domain-containing protein

1

14

High-throughput

0.479

High

954397

Q8MXJ7
Aldehyde dehydrogenase

1

4

High-throughput

0.479

High

954407

Q9BHK7
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

954408

Q9BI98
BPL/LPL catalytic domain-containing protein

1

1

High-throughput

0.479

High

954416

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.479

High

954420

Q9U2T9
Intersectin-1

1

9

High-throughput

0.479

High

954421

LIN41
Protein lin-41

1

8

Small-scale

0.479

High

785320

CED9
Apoptosis regulator ced-9

1

0

Small-scale

0.460

High

106205

2AB1
Serine/threonine-protein phosphatase 2A regulatory subunit sur-6

1

0

Small-scale

0.458

High

184311

O17003
Protein MAK10 homolog

1

0

High-throughput

0.458

High

954378

INX3
Innexin-3

1

0

High-throughput

0.458

High

954393

Q86G90
Nuclear Pore complex Protein

1

0

High-throughput

0.458

High

954396

Q8MQ11
Deoxynucleoside kinase domain-containing protein

1

0

High-throughput

0.458

High

954405

Q95YA9
C-CAP/cofactor C-like domain-containing protein

1

0

High-throughput

0.458

High

69034

A8WI68
Calcium-transporting ATPase

1

3

High-throughput

0.437

High

105314

G5ECM6
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.437

High

106057

G5EDF5
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.437

High

106853

G5EEH6
Isovaleryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

107342

LIN22
Helix-loop-helix protein lin-22

1

3

High-throughput

0.437

High

107858

G5EFS5
B30.2/SPRY domain-containing protein

1

1

High-throughput

0.437

High

109578

H2KYP3
Calx-beta domain-containing protein

1

1

High-throughput

0.437

High

111032

I2HA92
Ubiquitin carboxyl-terminal hydrolase

1

13

High-throughput

0.437

High

136667

SSP1B
FACT complex subunit ssrp1-B

1

5

High-throughput

0.437

High

219546

O44549
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

219553

O44565
Laminin subunit beta-1

1

2

High-throughput

0.437

High

219928

O45181
RRM domain-containing protein

1

6

High-throughput

0.437

High

404268

VIT2
Vitellogenin-2

1

3

High-throughput

0.437

High

410536

VIT5
Vitellogenin-5

1

3

High-throughput

0.437

High

489870

MYSP
Paramyosin

1

17

High-throughput

0.437

High

579913

VIT6
Vitellogenin-6

1

3

High-throughput

0.437

High

712296

ECHM
Probable enoyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.437

High

712344

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.437

High

736220

LEC1
32 kDa beta-galactoside-binding lectin

1

5

High-throughput

0.437

High

804423

AL7A1
Putative aldehyde dehydrogenase family 7 member A1 homolog

1

4

High-throughput

0.437

High

837257

PHB2
Mitochondrial prohibitin complex protein 2

1

6

High-throughput

0.437

High

837581

CH60
Chaperonin homolog Hsp-60, mitochondrial

1

5

High-throughput

0.437

High

855591

MMSA
Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

4

High-throughput

0.437

High

953812

GPDM
Probable glycerol-3-phosphate dehydrogenase, mitochondrial

1

5

High-throughput

0.437

High

954359

PWP2
Periodic tryptophan protein 2 homolog

1

8

High-throughput

0.437

High

954362

GYF1
GYF domain-containing protein gyf-1

1

17

High-throughput

0.437

High

954364

HMGBH
High mobility group protein 1.2

1

4

High-throughput

0.437

High

954365

Q09603
ACB domain-containing protein

1

2

High-throughput

0.437

High

954368

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

1

High-throughput

0.437

High

954370

NU214
Nuclear pore complex protein 14

1

1

High-throughput

0.437

High

954374

RSP6
Probable splicing factor, arginine/serine-rich 6

1

6

High-throughput

0.437

High

954377

CUT3
Cuticlin-3

1

2

High-throughput

0.437

High

954379

Q20049
Isocitrate dehydrogenase [NAD] subunit, mitochondrial

1

3

High-throughput

0.437

High

954382

Q20778
Nematode cuticle collagen N-terminal domain-containing protein

1

1

High-throughput

0.437

High

954383

Q20943
Multidrug resistance-associated protein 1

1

1

High-throughput

0.437

High

954385

GABT
Probable 4-aminobutyrate aminotransferase, mitochondrial

1

1

High-throughput

0.437

High

954389

Q22370
Peptidase M16 N-terminal domain-containing protein

1

1

High-throughput

0.437

High

954390

Q2L6Y6
Histidine kinase/HSP90-like ATPase domain-containing protein

1

10

High-throughput

0.437

High

954391

Q7JNG1
ATP synthase subunit O, mitochondrial

1

1

High-throughput

0.437

High

954394

Q86GU3
alanine transaminase

1

1

High-throughput

0.437

High

954395

Q8MNT7
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

2

High-throughput

0.437

High

954398

Q8MXS0
Calcium-transporting ATPase

1

2

High-throughput

0.437

High

954400

IDH3B
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

2

High-throughput

0.437

High

954402

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

3

High-throughput

0.437

High

954403

Q94216
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.437

High

954406

Q966K5
Nematode cuticle collagen N-terminal domain-containing protein

1

1

High-throughput

0.437

High

954409

PHB1
Mitochondrial prohibitin complex protein 1

1

6

High-throughput

0.437

High

954410

Q9GPA4
Trichohyalin

1

16

High-throughput

0.437

High

954411

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

954413

Q9N5T2
AAA domain-containing protein

1

1

High-throughput

0.437

High

954418

Q9U1Y6
Retinol dehydrogenase 13

1

3

High-throughput

0.437

High

954423

Q9XUE5
PAN domain protein

1

1

High-throughput

0.437

High

954424

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.437

High

954426

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.437

High

137019

O01902
BLOC-1-related complex subunit 5

2

0

High-throughput

0.300

High

60861

SIN3
Paired amphipathic helix protein sin-3

1

0

High-throughput

0.249

Low

87170

C7FZU5
TspO/MBR family protein

1

0

High-throughput

0.249

Low

105441

G5ECS9
Calponin-homology

1

0

High-throughput

0.249

Low

106177

NLTP2
Non-specific lipid-transfer protein-like 2

1

0

High-throughput

0.249

Low

136777

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.249

Low

136827

O01796
LisH domain-containing protein

1

0

High-throughput

0.249

Low

137093

EMR1
Emerin homolog 1

1

0

High-throughput

0.249

Low

137536

O02267
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.249

Low

137730

O02642
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

184451

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

184570

O17568
Uncharacterized protein

1

0

High-throughput

0.249

Low

184691

O17643
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.249

Low

218395

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

247927

O62071
PeriCentriolar MatriX Deficient

1

0

High-throughput

0.249

Low

711868

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.249

Low

785060

HCDH2
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3

1

0

High-throughput

0.249

Low

862981

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

954363

YRS3
Uncharacterized protein T05H10.3

1

0

High-throughput

0.249

Low

954366

Q09979
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.249

Low

954367

GCP
Bifunctional glyoxylate cycle protein

1

0

High-throughput

0.249

Low

954369

Q17411
Uncharacterized protein

1

0

High-throughput

0.249

Low

954371

Q17763
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

954372

Q18032
Protein sleepless

1

0

High-throughput

0.249

Low

954373

Q18036
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.249

Low

954375

Q18853
Cytochrome c domain-containing protein

1

0

High-throughput

0.249

Low

954381

Q20713
Conserved plasma membrane protein

1

0

High-throughput

0.249

Low

954386

Q21463
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.249

Low

954392

Q86D01
Cilia- and flagella-associated protein 157

1

0

High-throughput

0.249

Low

954399

Q8MXV3
CEntrosomal Protein

1

0

High-throughput

0.249

Low

954401

Q93540
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.249

Low

954404

Q95Q55
TraB domain-containing protein

1

0

High-throughput

0.249

Low

954412

Q9N3H3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

954414

Q9NAP4
Clc-like protein

1

0

High-throughput

0.249

Low

954415

TIM22
Mitochondrial import inner membrane translocase subunit tim-22

1

0

High-throughput

0.249

Low

954417

PGL1
Guanyl-specific ribonuclease pgl-1

1

0

High-throughput

0.249

Low

954419

Q9U238
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

954425

F161
Protein fam-161

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024