HitPredict

Interactor 1: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0017124 - SH3 domain binding GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 366
+	Hs
		1350201 EVL_HUMAN (1-375): 2.06e-60: 202: 43.68		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		1345493 HOME2_HUMAN (1-162): 1.41e-59: 198: 23.64		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		1205736 HOME1_HUMAN (1-182): 5.61e-51: 175: 23.24		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		1345512 HOME3_HUMAN (3-294): 6.76e-48: 168: 18.54		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		282318 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13
+	Hs
		282344 SPRE1_HUMAN (2-343): 2.84e-90: 280: 15.66		NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13
+	Hs
		840586 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		840522 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		840452 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		282372 HOME3_HUMAN (3-294): 6.76e-48: 168: 18.54		NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13
+	Mm
		1142989 DYN3_MOUSE (15-212): 1.14e-38: 149: 20.49		PACN1_MOUSE (11-363): 2.83e-36: 138: 11.86
+	Rn
		996551 DYN3_RAT (14-212): 2.29e-38: 148: 20.39		PACN1_RAT (11-363): 4.86e-36: 137: 11.86
+	Hs
		1191864 EVL_HUMAN (1-375): 2.06e-60: 202: 43.68		SH3R1_HUMAN (254-363): 8.79e-14: 74.7: 20.91
+	Hs
		1345510 HOME3_HUMAN (3-294): 6.76e-48: 168: 18.54		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		1205704 HOME1_HUMAN (1-182): 5.61e-51: 175: 23.24		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		1224647 HOME3_HUMAN (3-294): 6.76e-48: 168: 18.54		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		1307442 DYN3_HUMAN (15-212): 2.77e-38: 148: 20.98		SH3G2_HUMAN (265-363): 7.89e-26: 108: 23.76
+	Dm
		1250361 ENA_DROME (2-235): 1.21e-41: 158: 36.33		Q9Y0S9_DROME (260-364): 1.16e-20: 94.7: 38.32
+	Mm
		1141147 DYN3_MOUSE (15-212): 1.14e-38: 149: 20.49		GRB2_MOUSE (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		924956 DYN3_HUMAN (15-212): 2.77e-38: 148: 20.98		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30