HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: FNBP1 (Q96RU3)
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
Gene: FNBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	16418535, 15252009
Identification Methods	pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 617
+	Hs
		840723 DYN2_HUMAN (1-870): 0: 1057: 100.00		FBP1L_HUMAN (1-617): 4.85e-111: 347: 53.96
+	Hs
		983403 DYN1_HUMAN (1-846): 0: 1002: 79.04		FNBP1_HUMAN (1-617): 1.21e-118: 367: 100.00
+	Hs
		840700 DYN2_HUMAN (1-870): 0: 1057: 100.00		CIP4_HUMAN (1-611): 2.79e-95: 306: 49.84
+	Hs
		840683 DYN2_HUMAN (1-870): 0: 1057: 100.00		MYO1E_HUMAN (86-609): 3.26e-49: 186: 13.58
+	Hs
		840753 DYN2_HUMAN (1-870): 0: 1057: 100.00		FCSD1_HUMAN (7-607): 1.76e-48: 181: 12.42
+	Mm
		760475 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN1_MOUSE (178-607): 1.31e-36: 144: 11.86
+	Hs
		840812 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN1_HUMAN (178-607): 1.1e-35: 141: 12.09
+	Hs
		983372 DYN1_HUMAN (1-846): 0: 1002: 79.04		MYO1E_HUMAN (86-609): 3.26e-49: 186: 13.58
+	Hs
		840864 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Mm
		760487 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN2_MOUSE (268-607): 1.11e-22: 103: 12.43
+	Mm
		760451 DYN1_MOUSE (1-844): 0: 1003: 79.23		PACN1_MOUSE (178-607): 1.31e-36: 144: 11.86
+	Hs
		983406 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN1_HUMAN (178-607): 1.1e-35: 141: 12.09
+	Rn
		599414 DYN1_RAT (1-846): 0: 994: 78.57		PACN1_RAT (178-607): 2.37e-36: 143: 11.86
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (7-615): 1.35e-14: 79.9: 9.76
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (533-615): 2.01e-14: 79.1: 18.07
+	Hs
		207784 DYN2_HUMAN (1-870): 0: 1057: 100.00		PPIP1_HUMAN (286-607): 8.11e-11: 66.6: 13.53
+	Hs
		983417 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN2_HUMAN (179-607): 1.4e-23: 106: 11.26
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (7-615): 1.35e-14: 79.9: 9.76
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (533-615): 2.01e-14: 79.1: 18.07
+	Hs
		983392 DYN1_HUMAN (1-846): 0: 1002: 79.04		NOSTN_HUMAN (403-607): 2.23e-09: 62.2: 17.84