HitPredict

Interactor 1: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Interactor 2: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 147
+	Hs
		842121 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2V2_HUMAN (4-147): 8.54e-72: 213: 88.89
+	Hs
		842095 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27
+	Hs
		842104 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96
+	Hs
		930278 R144B_HUMAN (3-285): 2.41e-87: 264: 54.77		UBC9_HUMAN (9-145): 2.94e-54: 169: 21.01
+	Hs
		919876 RN19A_HUMAN (16-276): 5.96e-75: 246: 25.00		UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96
+	Hs
		919757 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96
+	Hs
		895819 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96
+	Hs
		849498 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27
+	Hs
		312679 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D4_HUMAN (12-146): 4.26e-58: 178: 24.44
+	Hs
		312520 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D1_HUMAN (12-147): 1.15e-57: 177: 24.27
+	Hs
		312553 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D2_HUMAN (12-146): 1.25e-56: 175: 22.96
+	Hs
		895968 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96
+	Hs
		1297383 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61
+	Hs
		312528 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D3_HUMAN (12-146): 3.82e-56: 173: 22.96
+	Hs
		312639 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E3_HUMAN (1-145): 1.38e-54: 172: 22.76
+	Hs
		312645 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E2_HUMAN (2-145): 1.8e-54: 171: 23.61
+	Mm
		854557 ARI2_MOUSE (2-231): 6.8e-64: 210: 25.96		UB2E3_MOUSE (1-145): 1.38e-54: 172: 22.76
+	Hs
		312597 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2V1_HUMAN (1-147): 1.08e-54: 170: 100.00
+	Hs
		312522 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E1_HUMAN (7-124): 1.45e-12: 63.8: 29.37
+	Mm
		854551 ARI2_MOUSE (2-231): 6.8e-64: 210: 25.96		UB2E1_MOUSE (7-124): 1.13e-12: 63.8: 29.37