HitPredict

Interactor 1: RASA1 (P50904)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Interactor 2: DOK1 (Q4QQV2)
Docking protein 1 (Downstream of tyrosine kinase 1)
Gene: DOK1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	12008030, 11970986, 16407976
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Rn			1 480
+	Mm
		93305 E9PYG6_MOUSE (1-1038): 0: 837: 98.65		DOK1_MOUSE (1-480): 0: 550: 93.78
+	Hs
		596429 RASA1_HUMAN (1-1038): 0: 806: 94.27		DOK1_HUMAN (1-480): 0: 548: 84.20
+	Mm
		93301 E9PYG6_MOUSE (1-1038): 0: 837: 98.65		DOK2_MOUSE (2-415): 6.12e-111: 336: 32.86
+	Hs
		235043 RASA1_HUMAN (1-1038): 0: 806: 94.27		DOK2_HUMAN (2-414): 2.23e-112: 339: 34.66
+	Hs
		789086 ABL2_HUMAN (2-286): 5.53e-26: 117: 19.93		DOK1_HUMAN (1-480): 0: 548: 84.20
+	Hs
		986022 PTN11_HUMAN (159-319): 3.53e-25: 113: 25.57		DOK1_HUMAN (1-480): 0: 548: 84.20
+	Mm
		956523 Q91YX7_MOUSE (87-587): 7.34e-19: 94.4: 12.67		DOK1_MOUSE (1-480): 0: 550: 93.78
+	Mm
		250956 Q91YX7_MOUSE (87-587): 7.34e-19: 94.4: 12.67		DOK2_MOUSE (2-415): 6.12e-111: 336: 32.86
+	Hs
		151763 GRB2_HUMAN (172-308): 8.28e-11: 64.7: 30.71		IRS4_HUMAN (6-403): 6.17e-98: 322: 13.95
+	Rn
		724630 PTN11_RAT (159-319): 3.53e-25: 113: 25.57		IRS1_RAT (6-365): 1.16e-78: 268: 14.36
+	Hs
		724535 PTN11_HUMAN (159-319): 3.53e-25: 113: 25.57		IRS1_HUMAN (6-360): 3.28e-78: 267: 14.88
+	Rn
		94387 PTN11_RAT (159-319): 3.53e-25: 113: 25.57		F1MAL5_RAT (6-370): 1.3e-69: 242: 14.46
+	Hs
		986064 PTN11_HUMAN (159-319): 3.53e-25: 113: 25.57		IRS2_HUMAN (6-368): 1.94e-67: 236: 14.18
+	Rn
		724631 GRB2_RAT (172-308): 8.28e-11: 64.7: 30.71		IRS1_RAT (6-365): 1.16e-78: 268: 14.36
+	Rn
		88883 PTN11_RAT (159-319): 3.53e-25: 113: 25.57		D4A244_RAT (172-463): 4.39e-60: 207: 23.99
+	Hs
		985997 PTN11_HUMAN (159-319): 3.53e-25: 113: 25.57		FRS2_HUMAN (172-463): 2.72e-59: 204: 21.96
+	Rn
		94388 GRB2_RAT (172-308): 8.28e-11: 64.7: 30.71		F1MAL5_RAT (6-370): 1.3e-69: 242: 14.46
+	Mm
		719314 PTN11_MOUSE (337-470): 4.51e-20: 97.5: 27.86		FRS2_MOUSE (172-463): 4.58e-58: 201: 23.31
+	Hs
		207310 PTN11_HUMAN (159-319): 3.53e-25: 113: 25.57		FRS3_HUMAN (172-435): 1.58e-44: 164: 18.89
+	Rn
		88884 GRB2_RAT (172-308): 8.28e-11: 64.7: 30.71		D4A244_RAT (172-463): 4.39e-60: 207: 23.99