HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	12446718
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0051726 - regulation of cell cycle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 784
+	Hs
		1226646 EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37		E4F1_HUMAN (1-784): 0: 588: 100.00
+	Hs
		842810 CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00		ZN420_HUMAN (1-391): 8.09e-160: 481: 15.09
+	Hs
		1402844 ANR26_HUMAN (3-155): 9.54e-35: 129: 18.71		ZN607_HUMAN (304-783): 7.82e-165: 495: 15.35
+	Hs
		1217764 EHMT1_HUMAN (15-147): 1.06e-33: 126: 25.00		GFI1B_HUMAN (192-266): 2.91e-10: 64.3: 36.00
+	Hs
		1217756 EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37		GFI1B_HUMAN (192-266): 2.91e-10: 64.3: 36.00
+	Hs
		1396290 EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37		GFI1_HUMAN (169-267): 2.45e-09: 62.4: 37.00