Protein: E4F1
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)

Gene: E4F1
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q66K89

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208850

ZBT24
Zinc finger and BTB domain-containing protein 24

2

20

High-throughput

0.811

High

340509

ZBT11
Zinc finger and BTB domain-containing protein 11

2

8

High-throughput

0.811

High

997780

CSK21
Casein kinase II subunit alpha

2

5

High-throughput

0.811

High

1226622

ZN770
Zinc finger protein 770

2

4

High-throughput

0.811

High

1226624

ZSC25
Zinc finger and SCAN domain-containing protein 25

2

19

High-throughput

0.811

High

1226625

ZN574
Zinc finger protein 574

2

4

High-throughput

0.811

High

1226627

ZN771
Zinc finger protein 771

2

19

High-throughput

0.811

High

1226633

ZN579
Zinc finger protein 579

2

5

High-throughput

0.811

High

1226645

HIC2
Hypermethylated in cancer 2 protein

2

20

High-throughput

0.811

High

1226649

GZF1
GDNF-inducible zinc finger protein 1

2

14

High-throughput

0.811

High

1226659

ZNF70
Zinc finger protein 70

2

7

High-throughput

0.811

High

414013

P53
Cellular tumor antigen p53

3

8

Small-scale

0.669

High

1123004

FHL2
Four and a half LIM domains protein 2

2

5

Small-scale

0.644

High

1109814

HDAC1
Histone deacetylase 1

2

8

Small-scale

0.634

High

290596

SURF6
Surfeit locus protein 6

2

3

High-throughput

0.628

High

599803

YBOX3
Y-box-binding protein 3

2

10

High-throughput

0.628

High

969916

RS16
Small ribosomal subunit protein uS9

2

3

High-throughput

0.628

High

987070

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

1

High-throughput

0.628

High

994597

YBOX1
Y-box-binding protein 1

2

10

High-throughput

0.628

High

1016053

RL19
Large ribosomal subunit protein eL19

2

5

High-throughput

0.628

High

1037199

H11
Histone H1.1

2

10

High-throughput

0.628

High

1179693

LIN41
E3 ubiquitin-protein ligase TRIM71

2

20

High-throughput

0.628

High

1194147

LARP7
La-related protein 7

2

2

High-throughput

0.628

High

1226640

VWCE
von Willebrand factor C and EGF domain-containing protein

2

20

High-throughput

0.628

High

1226648

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

2

High-throughput

0.628

High

1226654

DDX21
Nucleolar RNA helicase 2

2

4

High-throughput

0.628

High

1226660

ABT1
Activator of basal transcription 1

2

2

High-throughput

0.628

High

790058

ZEB1
Zinc finger E-box-binding homeobox 1

1

19

Small-scale

0.618

High

960143

RL26
Large ribosomal subunit protein uL24

2

6

High-throughput

0.611

High

902496

RT29
Small ribosomal subunit protein mS29

2

0

High-throughput

0.602

High

969266

RS8
Small ribosomal subunit protein eS8

2

0

High-throughput

0.602

High

1058077

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.602

High

1226631

ZC3H8
Zinc finger CCCH domain-containing protein 8

2

0

High-throughput

0.602

High

1226642

PTCD3
Small ribosomal subunit protein mS39

2

0

High-throughput

0.602

High

400984

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.575

High

1011813

RT05
Small ribosomal subunit protein uS5m

2

1

High-throughput

0.574

High

1012861

RT09
Small ribosomal subunit protein uS9m

2

3

High-throughput

0.574

High

1086416

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

20

High-throughput

0.574

High

1226628

LTBP4
Latent-transforming growth factor beta-binding protein 4

2

20

High-throughput

0.574

High

1226637

RT31
Small ribosomal subunit protein mS31

2

1

High-throughput

0.574

High

1226664

RT02
Small ribosomal subunit protein uS2m

2

2

High-throughput

0.574

High

1226665

RT18C
Small ribosomal subunit protein bS18m

2

2

High-throughput

0.574

High

442748

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.573

High

396305

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

1226655

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.569

High

903391

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

2

Small-scale

0.561

High

1226661

RL26L
Ribosomal protein uL24-like

2

6

High-throughput

0.558

High

915457

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.554

High

842786

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

6

Small-scale

0.552

High

487419

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.537

High

257883

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

High-throughput

0.536

High

285957

SF3B1
Splicing factor 3B subunit 1

1

2

High-throughput

0.536

High

615829

RL17
Large ribosomal subunit protein uL22

1

5

High-throughput

0.536

High

686624

ELAV4
ELAV-like protein 4

1

1

High-throughput

0.536

High

959824

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.536

High

1047577

NOTC2
Neurogenic locus notch homolog protein 2

1

16

High-throughput

0.536

High

1133982

ZN638
Zinc finger protein 638

1

1

High-throughput

0.536

High

1226630

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

5

High-throughput

0.536

High

1226638

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.536

High

1226647

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

1102186

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.516

High

813471

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

Small-scale

0.515

High

973209

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

982702

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.513

High

1226667

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

181899

SMAD9
Mothers against decapentaplegic homolog 9

1

3

High-throughput

0.508

High

502387

H2A1
Histone H2A type 1

1

2

High-throughput

0.489

High

1011466

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.489

High

1132093

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

20

High-throughput

0.489

High

1226626

H1FNT
Testis-specific H1 histone

1

3

High-throughput

0.489

High

1226652

MOV10
Helicase MOV-10

1

1

High-throughput

0.489

High

1226656

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

16

High-throughput

0.489

High

1226657

RBM28
RNA-binding protein 28

1

3

High-throughput

0.489

High

1226646

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

7

High-throughput

0.481

High

810159

RL3
Large ribosomal subunit protein uL3

1

6

High-throughput

0.479

High

979816

H4
Histone H4

1

2

High-throughput

0.479

High

1226623

Q6IT96
Histone deacetylase

1

8

Small-scale

0.479

High

1226629

LNX2
Ligand of Numb protein X 2

1

4

Small-scale

0.479

High

1226635

LNX1
E3 ubiquitin-protein ligase LNX

1

5

Small-scale

0.479

High

1226643

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

Small-scale

0.479

High

1226651

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

1161491

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1226636

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

950288

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.439

High

1226658

RRBP1
Ribosome-binding protein 1

1

6

High-throughput

0.437

High

1008192

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.408

High

1109457

ATR
Serine/threonine-protein kinase ATR

1

3

Small-scale

0.408

High

1011101

RT22
Small ribosomal subunit protein mS22

2

0

High-throughput

0.328

High

1011631

RT35
Small ribosomal subunit protein mS35

2

0

High-throughput

0.328

High

1012196

RT11
Small ribosomal subunit protein uS11m

2

0

High-throughput

0.328

High

1226641

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.328

High

1226650

RPF1
Ribosome production factor 1

2

0

High-throughput

0.328

High

1226662

RT33
Small ribosomal subunit protein mS33

2

0

High-throughput

0.328

High

1226663

RT07
Small ribosomal subunit protein uS7m

2

0

High-throughput

0.328

High

1226666

RT23
Small ribosomal subunit protein mS23

2

0

High-throughput

0.328

High

1226639

RL36L
Ribosomal protein eL42-like

2

0

High-throughput

0.318

High

1226653

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

338137

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.279

Low

1011287

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.279

Low

1226632

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.279

Low

1226644

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.279

Low

1226634

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025