HitPredict

Interactor 1: TCPQ (P50990)
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)
Gene: CCT8

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 548 Hs			1 1512
+	Hs
		826642 TCPG_HUMAN (10-547): 0: 558: 28.21		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		821191 TCPE_HUMAN (2-524): 0: 535: 29.62		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		843182 TCPD_HUMAN (19-525): 0: 530: 28.24		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		573242 TCPA_HUMAN (21-541): 0: 528: 29.89		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Dm
		1179613 Q7K3J0_DROME (1-544): 0: 553: 61.65		AKT1_DROME (970-1510): 8.64e-126: 407: 17.03
+	Hs
		625245 TCPQ_HUMAN (1-548): 0: 616: 100.00		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Dm
		1213398 Q9VHL2_DROME (12-532): 0: 527: 26.65		AKT1_DROME (970-1510): 8.64e-126: 407: 17.03
+	Hs
		625579 TCPH_HUMAN (9-538): 0: 564: 26.39		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		625228 TCPG_HUMAN (10-547): 0: 558: 28.21		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		625220 TCPE_HUMAN (2-524): 0: 535: 29.62		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		625246 TCPD_HUMAN (19-525): 0: 530: 28.24		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		573132 TCPA_HUMAN (21-541): 0: 528: 29.89		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		843013 TCPQ_HUMAN (1-548): 0: 616: 100.00		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		1306370 TCPH_HUMAN (9-538): 0: 564: 26.39		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		826842 TCPG_HUMAN (10-547): 0: 558: 28.21		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		821380 TCPE_HUMAN (2-524): 0: 535: 29.62		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		843350 TCPD_HUMAN (19-525): 0: 530: 28.24		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Hs
		573438 TCPA_HUMAN (21-541): 0: 528: 29.89		M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03
+	Sc
		792398 TCPH_YEAST (7-542): 0: 534: 28.34		BCK1_YEAST (1233-1506): 4.35e-44: 178: 39.01
+	Hs
		1302200 TCPQM_HUMAN (32-545): 7.5e-75: 249: 32.17		M3K4_HUMAN (1242-1505): 6.41e-38: 158: 33.21