Protein: FCN1
Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)

Gene: FCN1
Organism: Homo sapiens
Interactions: 78
UniProt ID: O00602

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0001867 - complement activation, lectin pathway
GO:0002752 - cell surface pattern recognition receptor signaling pathway
GO:0003823 - antigen binding
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

141987

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

3

4

High-throughput

0.861

High

142003

FCN2
Ficolin-2

3

17

High-throughput

0.861

High

62855

POTEF
POTE ankyrin domain family member F

3

2

High-throughput

0.667

High

141968

DJC13
DnaJ homolog subfamily C member 13

3

1

High-throughput

0.667

High

141985

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

3

4

High-throughput

0.667

High

142011

SE6L2
Seizure 6-like protein 2

3

14

High-throughput

0.667

High

142028

K1549
UPF0606 protein KIAA1549

3

3

High-throughput

0.667

High

141972

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.656

High

141976

FINC
Fibronectin

1

9

Small-scale

0.647

High

141880

PODXL
Podocalyxin

3

0

High-throughput

0.638

High

142016

K319L
Dyslexia-associated protein KIAA0319-like protein

3

0

High-throughput

0.638

High

141962

FCN1
Ficolin-1

1

16

Small-scale

0.590

High

142008

KLH22
Kelch-like protein 22

2

2

High-throughput

0.549

High

141975

CRP

1

5

Small-scale

0.536

High

137009

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

2

High-throughput

0.536

High

141971

IGJ
Immunoglobulin J chain

1

1

High-throughput

0.536

High

141977

TRFL
Lactotransferrin

1

3

High-throughput

0.536

High

141981

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.536

High

141992

LCN1
Lipocalin-1

1

1

High-throughput

0.536

High

141997

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.536

High

142000

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.536

High

142018

BPIB1
BPI fold-containing family B member 1

1

2

High-throughput

0.536

High

142021

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

1

High-throughput

0.536

High

125796

MASP2
Mannan-binding lectin serine protease 2

1

12

Small-scale

0.515

High

141994

MASP1
Mannan-binding lectin serine protease 1

1

14

Small-scale

0.515

High

142012

NUD18
8-oxo-dGDP phosphatase NUDT18

1

0

High-throughput

0.513

High

126269

TLR4
Toll-like receptor 4

1

5

Small-scale

0.501

High

141980

UROM
Uromodulin

1

13

Small-scale

0.501

High

141983

ELN
Elastin

1

2

Small-scale

0.501

High

142025

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

2

High-throughput

0.489

High

141986

FBLN1
Fibulin-1

1

9

High-throughput

0.479

High

141990

PTX3
Pentraxin-related protein PTX3

1

5

Small-scale

0.479

High

141963

MA2B1
Lysosomal alpha-mannosidase

1

2

Small-scale

0.457

High

141965

FFAR2
Free fatty acid receptor 2

1

4

Small-scale

0.457

High

141974

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

Small-scale

0.457

High

141984

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.457

High

141991

GRAN
Grancalcin

1

2

Small-scale

0.457

High

141999

TNFC
Lymphotoxin-beta

1

1

Small-scale

0.457

High

142002

MBTP1
Membrane-bound transcription factor site-1 protease

1

3

Small-scale

0.457

High

142004

ZYX
Zyxin

1

2

Small-scale

0.457

High

142022

PDLI5
PDZ and LIM domain protein 5

1

2

Small-scale

0.457

High

142024

EMIL2
EMILIN-2

1

4

Small-scale

0.457

High

142029

WDR6
tRNA

1

1

Small-scale

0.457

High

142030

MMP25
Matrix metalloproteinase-25

1

2

Small-scale

0.457

High

142032

STK24
Serine/threonine-protein kinase 24

1

7

Small-scale

0.457

High

141970

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

Small-scale

0.445

High

141973

IGKC
Immunoglobulin kappa constant

1

3

High-throughput

0.445

High

142001

CUL3
Cullin-3

1

2

High-throughput

0.445

High

141978

MT2
Metallothionein-2

1

0

Small-scale

0.438

High

141979

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

141988

COF1
Cofilin-1

1

0

Small-scale

0.438

High

141989

FSHR
Follicle-stimulating hormone receptor

1

0

Small-scale

0.438

High

141993

ARL4A
ADP-ribosylation factor-like protein 4A

1

0

Small-scale

0.438

High

141998

IN35
Interferon-induced 35 kDa protein

1

0

Small-scale

0.438

High

142009

PVRIG
Transmembrane protein PVRIG

1

0

Small-scale

0.438

High

142031

HCST
Hematopoietic cell signal transducer

1

0

Small-scale

0.438

High

142015

GT252
Procollagen galactosyltransferase 2

1

2

High-throughput

0.437

High

141982

TDGF1
Protein Cripto

1

0

High-throughput

0.426

High

142019

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.426

High

141964

CCS
Copper chaperone for superoxide dismutase

1

1

Small-scale

0.417

High

142020

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

Small-scale

0.417

High

141967

VINEX
Vinexin

1

1

High-throughput

0.407

High

141966

SUSD5
Sushi domain-containing protein 5

3

0

High-throughput

0.347

High

142027

TRABD
TraB domain-containing protein

2

0

High-throughput

0.328

High

141969

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

142017

CH058
Uncharacterized protein C8orf58

1

0

High-throughput

0.269

Low

142006

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.249

Low

64520

CC88B
Coiled-coil domain-containing protein 88B

1

0

Small-scale

0.238

Low

141995

GDIR2
Rho GDP-dissociation inhibitor 2

1

0

Small-scale

0.238

Low

141996

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

Small-scale

0.238

Low

142005

ZXDC
Zinc finger protein ZXDC

1

0

Small-scale

0.238

Low

142007

MIDN
Midnolin

1

0

Small-scale

0.238

Low

142014

ASXL1
Polycomb group protein ASXL1

1

0

Small-scale

0.238

Low

142023

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

Small-scale

0.238

Low

142026

I27L2
Interferon alpha-inducible protein 27-like protein 2

1

0

Small-scale

0.238

Low

142010

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.232

Low

142013

CHST3
Carbohydrate sulfotransferase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025