Protein: DNLI4
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)

Gene: DNLI4, LIG4
Organism: Homo sapiens
Interactions: 137
UniProt ID: P49917

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000287 - magnesium ion binding
GO:0000781 - chromosome, telomeric region
GO:0000793 - condensed chromosome
GO:0001701 - in utero embryonic development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836829

XRCC4
DNA repair protein XRCC4

22

1

Small-scale

0.992

High

523597

XRCC6
X-ray repair cross-complementing protein 6

4

6

Small-scale

0.886

High

524840

XRCC5
X-ray repair cross-complementing protein 5

3

6

Small-scale

0.827

High

836846

APLF
Aprataxin and PNK-like factor

5

1

Small-scale

0.716

High

836820

PRKDC
DNA-dependent protein kinase catalytic subunit

3

3

Small-scale

0.655

High

836867

DCR1C
Protein artemis

2

0

Small-scale

0.635

High

821940

KC1A
Casein kinase I isoform alpha

2

1

High-throughput

0.628

High

836877

NHEJ1
Non-homologous end-joining factor 1

3

0

Small-scale

0.622

High

836869

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

3

Small-scale

0.601

High

431310

LDHC
L-lactate dehydrogenase C chain

1

2

High-throughput

0.552

High

453222

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.552

High

583300

HXK1
Hexokinase-1

1

1

High-throughput

0.552

High

660951

AMPL
Cytosol aminopeptidase

1

1

High-throughput

0.552

High

734890

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.552

High

836818

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.552

High

836823

TLE4
Transducin-like enhancer protein 4

1

1

High-throughput

0.552

High

836825

TP53B
TP53-binding protein 1

1

2

High-throughput

0.552

High

836889

RUVB2
RuvB-like 2

1

2

High-throughput

0.552

High

311508

SMC2
Structural maintenance of chromosomes protein 2

1

0

Small-scale

0.549

High

836857

PHF10
PHD finger protein 10

1

4

High-throughput

0.541

High

836827

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.536

High

822220

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

836842

APTX
Aprataxin

1

3

High-throughput

0.536

High

836872

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

62016

PGP
Glycerol-3-phosphate phosphatase

1

0

High-throughput

0.529

High

417198

ENOA
Alpha-enolase

1

0

High-throughput

0.529

High

616048

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.529

High

836812

BTG1
Protein BTG1

1

0

High-throughput

0.529

High

836815

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.529

High

836832

THOC5
THO complex subunit 5 homolog

1

0

High-throughput

0.529

High

836838

AFTIN
Aftiphilin

1

0

High-throughput

0.529

High

836850

OXR1
Oxidation resistance protein 1

1

0

High-throughput

0.529

High

836858

PALLD
Palladin

1

0

High-throughput

0.529

High

836860

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.529

High

836870

NEUR1
Sialidase-1

1

0

High-throughput

0.529

High

836879

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.529

High

799184

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.518

High

836854

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

0

High-throughput

0.518

High

836856

ALMS1
Centrosome-associated protein ALMS1

1

1

High-throughput

0.504

High

836347

GRAK
Granzyme K

1

1

High-throughput

0.494

High

371159

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

1

High-throughput

0.481

High

474961

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.481

High

532435

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.481

High

609760

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

High-throughput

0.481

High

836808

IF4A1
Eukaryotic initiation factor 4A-I

1

1

High-throughput

0.481

High

836833

DGUOK
Deoxyguanosine kinase, mitochondrial

1

1

High-throughput

0.481

High

836855

WDR20
WD repeat-containing protein 20

1

1

High-throughput

0.481

High

836859

CBP
CREB-binding protein

1

2

High-throughput

0.481

High

836871

CPNE1
Copine-1

1

1

High-throughput

0.481

High

836880

DD19A
ATP-dependent RNA helicase DDX19A

1

1

High-throughput

0.481

High

334163

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.479

High

799062

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

836826

STRN3
Striatin-3

1

1

High-throughput

0.479

High

836868

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

307957

ZWINT
ZW10 interactor

1

0

High-throughput

0.460

High

381865

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.460

High

396902

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.460

High

500753

CLUS
Clusterin

1

0

High-throughput

0.460

High

708402

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.460

High

793791

CATK
Cathepsin K

1

0

High-throughput

0.460

High

836806

RBM5
RNA-binding protein 5

1

0

High-throughput

0.460

High

836809

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.460

High

836814

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.460

High

836816

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.460

High

836817

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

High-throughput

0.460

High

836821

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.460

High

836834

ATOSA
Atos homolog protein A

1

0

High-throughput

0.460

High

836836

RHBD2
Rhomboid domain-containing protein 2

1

0

High-throughput

0.460

High

836839

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.460

High

836845

AROS
Active regulator of SIRT1

1

0

High-throughput

0.460

High

836847

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

High-throughput

0.460

High

836848

SYCP3
Synaptonemal complex protein 3

1

0

High-throughput

0.460

High

836849

OGFD1
Prolyl 3-hydroxylase OGFOD1

1

0

High-throughput

0.460

High

836851

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.460

High

836852

ZFN2A
AN1-type zinc finger protein 2A

1

0

High-throughput

0.460

High

836864

MCRS1
Microspherule protein 1

1

0

High-throughput

0.460

High

836874

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

0

High-throughput

0.460

High

836883

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.460

High

836886

APC10
Anaphase-promoting complex subunit 10

1

0

High-throughput

0.460

High

836887

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.460

High

836888

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.460

High

836891

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.460

High

375911

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

430097

PROF1
Profilin-1

1

0

High-throughput

0.458

High

448307

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

598015

FLNA
Filamin-A

1

0

High-throughput

0.458

High

836807

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

836841

MICA3
[F-actin]-monooxygenase MICAL3

1

0

High-throughput

0.458

High

836843

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

836861

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

836863

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.458

High

836865

HIC2
Hypermethylated in cancer 2 protein

1

0

High-throughput

0.458

High

836885

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

371214

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

High-throughput

0.439

High

836828

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.439

High

282855

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.437

High

421996

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.437

High

580626

ML12A
Myosin regulatory light chain 12A

1

1

High-throughput

0.437

High

836837

PPR18
Phostensin

1

1

High-throughput

0.437

High

836840

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

836876

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

836875

PAXX
Protein PAXX

1

0

Small-scale

0.426

High

508399

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

836831

ATR
Serine/threonine-protein kinase ATR

1

3

Small-scale

0.408

High

208719

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.288

High

622660

ERD21
ER lumen protein-retaining receptor 1

1

0

High-throughput

0.288

High

836853

BBOF1
Basal body-orientation factor 1

1

0

High-throughput

0.288

High

203349

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

0

High-throughput

0.251

Low

234922

SNX3
Sorting nexin-3

1

0

High-throughput

0.251

Low

238603

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.251

Low

327049

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

0

High-throughput

0.251

Low

330309

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.251

Low

335666

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.251

Low

335796

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.251

Low

335987

COX3
Cytochrome c oxidase subunit 3

1

0

High-throughput

0.251

Low

371078

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.251

Low

436021

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.251

Low

836810

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.251

Low

836811

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.251

Low

836813

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.251

Low

836819

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.251

Low

836822

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.251

Low

836830

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.251

Low

836835

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

0

High-throughput

0.251

Low

836844

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.251

Low

836862

ZN428
Zinc finger protein 428

1

0

High-throughput

0.251

Low

836866

AGAP4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

1

0

High-throughput

0.251

Low

836873

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

High-throughput

0.251

Low

836878

SEM4G
Semaphorin-4G

1

0

High-throughput

0.251

Low

836881

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.251

Low

836882

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.251

Low

836884

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.251

Low

836890

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.251

Low

836892

IPP
Actin-binding protein IPP

1

0

High-throughput

0.251

Low

427059

CATD
Cathepsin D

1

0

High-throughput

0.249

Low

741845

TAGL2
Transgelin-2

1

0

High-throughput

0.249

Low

836824

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024