Protein: CDN2C
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)

Gene: CDN2C, CDKN2C
Organism: Homo sapiens
Interactions: 96
UniProt ID: P42773

Gene Ontology (top 5):
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549085

CDK4
Cyclin-dependent kinase 4

20

17

Small-scale

0.992

High

842952

CDK6
Cyclin-dependent kinase 6

21

17

Small-scale

0.991

High

842954

REL
Proto-oncogene c-Rel

3

10

High-throughput

0.881

High

250220

VINEX
Vinexin

2

20

High-throughput

0.783

High

842979

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

3

18

High-throughput

0.770

High

842900

CDN2B
Cyclin-dependent kinase 4 inhibitor B

2

15

High-throughput

0.768

High

842958

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.724

High

842960

ATR
Serine/threonine-protein kinase ATR

1

9

Small-scale

0.724

High

413357

P53
Cellular tumor antigen p53

1

14

High-throughput

0.698

High

229974

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

5

0

High-throughput

0.694

High

587020

ITF2
Transcription factor 4

3

2

High-throughput

0.683

High

842983

HTF4
Transcription factor 12

3

2

High-throughput

0.683

High

843001

NAGK
N-acetyl-D-glucosamine kinase

3

1

High-throughput

0.683

High

664670

CCND1
G1/S-specific cyclin-D1

3

12

High-throughput

0.667

High

718870

CCND3
G1/S-specific cyclin-D3

3

12

High-throughput

0.667

High

842992

NIF3L
NIF3-like protein 1

2

2

High-throughput

0.654

High

400438

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

18

High-throughput

0.647

High

410694

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

593304

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.647

High

728091

AKT1
RAC-alpha serine/threonine-protein kinase

1

14

High-throughput

0.647

High

842942

MK08
Mitogen-activated protein kinase 8

1

15

Small-scale

0.647

High

842943

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.647

High

842945

MK10
Mitogen-activated protein kinase 10

1

15

Small-scale

0.647

High

842964

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.647

High

842996

LATS2
Serine/threonine-protein kinase LATS2

1

13

High-throughput

0.647

High

842947

CASP6
Caspase-6

1

0

High-throughput

0.630

High

842999

COKA1

1

11

High-throughput

0.618

High

703478

MK01
Mitogen-activated protein kinase 1

1

10

High-throughput

0.618

High

842948

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

19

High-throughput

0.618

High

842974

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

842984

GA2L1
GAS2-like protein 1

2

10

High-throughput

0.611

High

209964

CRX
Cone-rod homeobox protein

2

15

High-throughput

0.606

High

842951

PO6F2
POU domain, class 6, transcription factor 2

2

5

High-throughput

0.606

High

842963

K1H1
Keratin, type I cuticular Ha1

2

12

High-throughput

0.606

High

842969

PKHG4
Puratrophin-1

2

5

High-throughput

0.606

High

842990

PBX4
Pre-B-cell leukemia transcription factor 4

2

4

High-throughput

0.606

High

842993

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

4

High-throughput

0.606

High

377027

NEU2
Vasopressin-neurophysin 2-copeptin

2

0

High-throughput

0.602

High

733837

CDD
Cytidine deaminase

2

0

High-throughput

0.602

High

842986

PYM1
Partner of Y14 and mago

2

0

High-throughput

0.602

High

648452

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.579

High

710111

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.579

High

842955

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.579

High

842976

PRSR2
Proline and serine-rich protein 2

2

1

High-throughput

0.574

High

842995

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.561

High

248384

GDF9
Growth/differentiation factor 9

1

2

High-throughput

0.541

High

539923

ARY2
Arylamine N-acetyltransferase 2

1

1

High-throughput

0.541

High

842949

NH2L1
NHP2-like protein 1

1

1

High-throughput

0.541

High

842950

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

11

High-throughput

0.541

High

842953

TLE1
Transducin-like enhancer protein 1

1

7

High-throughput

0.541

High

842959

U119A
Protein unc-119 homolog A

1

2

High-throughput

0.541

High

842975

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.541

High

842988

MTA3
Metastasis-associated protein MTA3

1

11

High-throughput

0.541

High

842994

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.541

High

842965

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.536

High

842981

RIN3
Ras and Rab interactor 3

1

10

High-throughput

0.536

High

843003

GPSM3
G-protein-signaling modulator 3

1

2

High-throughput

0.536

High

842961

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.518

High

130924

HIP1
Huntingtin-interacting protein 1

1

6

High-throughput

0.515

High

421665

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.515

High

842962

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

0

High-throughput

0.513

High

842977

DAAF8
Dynein axonemal assembly factor 8

1

0

High-throughput

0.513

High

842987

SPXN
Spexin

1

0

High-throughput

0.513

High

842997

BEX4
Protein BEX4

1

0

High-throughput

0.513

High

842978

LNX2
Ligand of Numb protein X 2

1

20

High-throughput

0.512

High

371396

MYC
Myc proto-oncogene protein

1

17

High-throughput

0.501

High

507649

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

High-throughput

0.501

High

666960

CCNE1
G1/S-specific cyclin-E1

1

3

High-throughput

0.501

High

693265

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

6

High-throughput

0.501

High

718776

CCND2
G1/S-specific cyclin-D2

1

9

High-throughput

0.501

High

767122

MERL
Merlin

1

20

High-throughput

0.501

High

842956

GRM1
Metabotropic glutamate receptor 1

1

3

High-throughput

0.501

High

842944

APLP1
Amyloid beta precursor like protein 1

1

6

High-throughput

0.494

High

842989

ANGL4
Angiopoietin-related protein 4

1

2

High-throughput

0.494

High

842991

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.494

High

843004

ST14
Suppressor of tumorigenicity 14 protein

1

1

High-throughput

0.494

High

842970

PPM1J
Protein phosphatase 1J

1

2

High-throughput

0.489

High

842982

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

843002

AT7L1
Ataxin-7-like protein 1

1

8

High-throughput

0.489

High

842680

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

17

High-throughput

0.479

High

842946

KAD2
Adenylate kinase 2, mitochondrial

1

7

High-throughput

0.479

High

842966

CDC37
Hsp90 co-chaperone Cdc37

1

7

High-throughput

0.479

High

843000

UBQL2
Ubiquilin-2

1

10

High-throughput

0.479

High

280536

PR40A
Pre-mRNA-processing factor 40 homolog A

1

14

High-throughput

0.470

High

561934

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.470

High

842980

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

842973

RIF1
Telomere-associated protein RIF1

1

16

High-throughput

0.457

High

842985

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.328

High

842957

SG2A2
Mammaglobin-A

1

0

High-throughput

0.282

High

842968

GREB1
Protein GREB1

1

0

High-throughput

0.282

High

842971

RBM48
RNA-binding protein 48

1

0

High-throughput

0.282

High

843005

LY96
Lymphocyte antigen 96

1

0

High-throughput

0.282

High

485929

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

842967

CART

1

0

High-throughput

0.279

Low

842972

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

842998

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025