HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: PRGC1 (Q9UBK2)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
Gene: PPARGC1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20203100
Identification Methods	amplified luminescent proximity homogeneous assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032922 - circadian regulation of gene expression GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0060612 - adipose tissue development
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 518 Hs			1 798
+	Hs
		130337 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		265882 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250730 STF1_MOUSE (24-503): 5.65e-91: 287: 20.37		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		740612 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		587203 RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250727 PPARA_MOUSE (17-118): 1.56e-42: 159: 48.54		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		992454 PPARA_HUMAN (29-118): 4.05e-42: 158: 53.85		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		975478 PPARD_HUMAN (29-133): 2.16e-41: 155: 47.17		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		500377 RARB_HUMAN (3-116): 7.14e-41: 154: 46.96		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		500508 THB_HUMAN (6-165): 2.41e-40: 153: 32.40		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250749 NR1H3_MOUSE (2-329): 6.29e-38: 146: 19.51		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Mm
		250732 PPARG_MOUSE (316-506): 2.91e-16: 83.2: 26.73		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		740551 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		992432 PPARA_HUMAN (29-118): 4.05e-42: 158: 53.85		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		500495 THB_HUMAN (6-165): 2.41e-40: 153: 32.40		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Mm
		1257603 NR1H3_MOUSE (2-329): 6.29e-38: 146: 19.51		PRGC2_MOUSE (237-467): 1.97e-54: 205: 29.74