HitPredict

Interactor 1: GNAO (P51875)
Guanine nucleotide-binding protein G(o) subunit alpha
Gene: goa-1

Interactor 2: RGS7 (Q8WQC0)
Regulator of G-protein signaling rgs-7 (Protein C2-RGS) (Regulator of G-protein signaling c2)
Gene: rgs-7

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	12798417, 15479638, 18984596
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0005938 - cell cortex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Ce			1 819
+	Hs
		277782 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS9_HUMAN (550-815): 6.23e-79: 270: 20.15
+	Hs
		283160 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS20_HUMAN (503-810): 1.35e-67: 231: 23.87
+	Hs
		283183 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS20_HUMAN (503-810): 1.35e-67: 231: 23.87
+	Hs
		450989 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS4_HUMAN (623-817): 2.92e-60: 204: 34.52
+	Hs
		158608 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS12_HUMAN (586-819): 2.93e-54: 206: 27.39
+	Hs
		834937 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS4_HUMAN (623-817): 2.92e-60: 204: 34.52
+	Rn
		834945 GNAO_RAT (1-354): 1.36e-172: 485: 81.92		RGS4_RAT (623-817): 2.79e-59: 201: 35.03
+	Rn
		500350 GNAI1_RAT (1-354): 3.1e-172: 484: 70.14		RGS4_RAT (623-817): 2.79e-59: 201: 35.03
+	Hs
		926720 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS18_HUMAN (603-814): 7.35e-59: 201: 30.23
+	Hs
		207517 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS14_HUMAN (658-816): 2.01e-54: 199: 34.78
+	Hs
		450988 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS19_HUMAN (584-809): 3.72e-56: 193: 24.78
+	Hs
		182443 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS5_HUMAN (623-801): 9.23e-56: 191: 31.35
+	Mm
		579645 GNAO_MOUSE (1-354): 2.66e-172: 484: 81.64		RGS16_MOUSE (623-817): 6.1e-57: 195: 33.33
+	Hs
		926723 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS17_HUMAN (604-810): 1.68e-56: 194: 26.09
+	Hs
		834879 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS19_HUMAN (584-809): 3.72e-56: 193: 24.78
+	Hs
		180653 GNAO_HUMAN (1-354): 2.13e-174: 490: 82.20		RGS16_HUMAN (623-799): 1.52e-53: 186: 32.60
+	Hs
		182448 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS5_HUMAN (623-801): 9.23e-56: 191: 31.35
+	Hs
		180657 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS16_HUMAN (623-799): 1.52e-53: 186: 32.60
+	Hs
		210414 GNAI1_HUMAN (1-354): 3.13e-172: 484: 69.86		RGS10_HUMAN (678-814): 9.01e-20: 89.4: 41.61
+	Mm
		579646 GNAO_MOUSE (1-354): 2.66e-172: 484: 81.64		RGS14_MOUSE (676-812): 1.01e-14: 79.7: 37.68