Protein: P2RY8
S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)

Gene: P2RY8
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q86VZ1

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0045028 - G protein-coupled purinergic nucleotide receptor activity
GO:0160221 - Rho-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618468

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

19

High-throughput

0.861

High

893500

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

20

High-throughput

0.789

High

723693

NTR1
Neurotensin receptor type 1

1

18

High-throughput

0.691

High

787314

ACV1B
Activin receptor type-1B

1

2

High-throughput

0.691

High

602240

TMM11
Transmembrane protein 11, mitochondrial

3

3

High-throughput

0.667

High

899664

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

3

20

High-throughput

0.667

High

1116940

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

3

20

High-throughput

0.667

High

1162295

AT2B3
Plasma membrane calcium-transporting ATPase 3

3

20

High-throughput

0.667

High

1291846

LRC15
Leucine-rich repeat-containing protein 15

3

1

High-throughput

0.667

High

1291903

SERC1
Serine incorporator 1

3

7

High-throughput

0.667

High

1291895

GOLP3
Golgi phosphoprotein 3

3

4

High-throughput

0.662

High

1102200

ATM
Serine-protein kinase ATM

4

20

High-throughput

0.630

High

355005

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.618

High

1291834

VRK2
Serine/threonine-protein kinase VRK2

1

2

High-throughput

0.618

High

1291873

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

3

High-throughput

0.618

High

570484

GFAP
Glial fibrillary acidic protein

3

2

High-throughput

0.609

High

1235405

ACD10
Acyl-CoA dehydrogenase family member 10

3

10

High-throughput

0.609

High

1291844

ATLA2
Atlastin-2

3

14

High-throughput

0.609

High

1291899

AT133
Polyamine-transporting ATPase 13A3

3

20

High-throughput

0.609

High

1291916

CS025
UPF0449 protein C19orf25

3

4

High-throughput

0.609

High

187532

FANCA
Fanconi anemia group A protein

3

6

High-throughput

0.593

High

1291891

METL9
Protein-L-histidine N-pros-methyltransferase

3

1

High-throughput

0.593

High

1291905

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

3

7

High-throughput

0.593

High

1291838

WDFY3
WD repeat and FYVE domain-containing protein 3

1

8

High-throughput

0.575

High

1201846

PKHG4
Puratrophin-1

2

6

High-throughput

0.571

High

326730

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.558

High

397608

NU1M
NADH-ubiquinone oxidoreductase chain 1

2

2

High-throughput

0.558

High

1245202

BRAT1
Integrator complex assembly factor BRAT1

2

6

High-throughput

0.558

High

1291835

DAAF5
Dynein axonemal assembly factor 5

2

7

High-throughput

0.558

High

1291883

FACD2
Fanconi anemia group D2 protein

2

10

High-throughput

0.558

High

208063

TTI1
TELO2-interacting protein 1 homolog

2

5

High-throughput

0.549

High

318144

IPO13
Importin-13

2

20

High-throughput

0.549

High

399706

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

7

High-throughput

0.549

High

1043147

TAP1
Antigen peptide transporter 1

2

11

High-throughput

0.549

High

1200262

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

20

High-throughput

0.549

High

1204573

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

2

12

High-throughput

0.549

High

1273951

DYM
Dymeclin

2

9

High-throughput

0.549

High

1291840

INT1
Integrator complex subunit 1

2

10

High-throughput

0.549

High

1291848

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

15

High-throughput

0.549

High

1291860

HOOK2
Protein Hook homolog 2

2

7

High-throughput

0.549

High

1291866

RUSF1
RUS family member 1

2

6

High-throughput

0.549

High

1291906

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

5

High-throughput

0.549

High

1291922

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

2

6

High-throughput

0.549

High

178314

NPC1
NPC intracellular cholesterol transporter 1

1

7

High-throughput

0.536

High

178557

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

9

High-throughput

0.536

High

184183

RER1
Protein RER1

1

3

High-throughput

0.536

High

230814

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

420012

B3A2
Anion exchange protein 2

1

6

High-throughput

0.536

High

565656

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

627366

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

20

High-throughput

0.536

High

661295

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

839309

MTOR
Serine/threonine-protein kinase mTOR

1

20

High-throughput

0.536

High

845068

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.536

High

931259

AT12A
Potassium-transporting ATPase alpha chain 2

1

20

High-throughput

0.536

High

1007580

PRAME
Melanoma antigen preferentially expressed in tumors

1

3

High-throughput

0.536

High

1023355

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.536

High

1031440

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.536

High

1032606

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

1105213

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.536

High

1154052

MSMO1
Methylsterol monooxygenase 1

1

6

High-throughput

0.536

High

1217147

RIF1
Telomere-associated protein RIF1

1

5

High-throughput

0.536

High

1217381

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

11

High-throughput

0.536

High

1242844

S39A4
Zinc transporter ZIP4

1

20

High-throughput

0.536

High

1259314

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.536

High

1291845

CIP2A
Protein CIP2A

1

8

High-throughput

0.536

High

1291859

COQ8B
Atypical kinase COQ8B, mitochondrial

1

12

High-throughput

0.536

High

1291864

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

1291868

EXOC2
Exocyst complex component 2

1

10

High-throughput

0.536

High

1291874

CHP1
Calcineurin B homologous protein 1

1

1

High-throughput

0.536

High

1291878

S39A3
Zinc transporter ZIP3

1

20

High-throughput

0.536

High

1291885

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.536

High

1291888

YIPF3
Protein YIPF3

1

9

High-throughput

0.536

High

1291894

PIGU
GPI-anchor transamidase component PIGU

1

4

High-throughput

0.536

High

1291912

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

4

High-throughput

0.536

High

1291914

ATX10
Ataxin-10

1

1

High-throughput

0.536

High

1291919

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.536

High

1291923

SC5A6
Sodium-dependent multivitamin transporter

1

3

High-throughput

0.536

High

814823

CUX1
Homeobox protein cut-like 1

2

10

High-throughput

0.521

High

562801

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

890011

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

1216220

H37
Histone H3-7

2

3

High-throughput

0.504

High

173720

BTAF1
TATA-binding protein-associated factor 172

1

10

High-throughput

0.489

High

178957

SCAM2
Secretory carrier-associated membrane protein 2

1

7

High-throughput

0.489

High

185209

FANCG
Fanconi anemia group G protein

1

1

High-throughput

0.489

High

186426

TM9S1
Transmembrane 9 superfamily member 1

1

14

High-throughput

0.489

High

189210

IPO8
Importin-8

1

20

High-throughput

0.489

High

220940

XPOT
Exportin-T

1

20

High-throughput

0.489

High

225373

ERD23
ER lumen protein-retaining receptor 3

1

8

High-throughput

0.489

High

281612

MTX2
Metaxin-2

1

9

High-throughput

0.489

High

301531

WFS1
Wolframin

1

3

High-throughput

0.489

High

316522

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.489

High

341437

CDS2
Phosphatidate cytidylyltransferase 2

1

1

High-throughput

0.489

High

344472

STR3N
STARD3 N-terminal-like protein

1

1

High-throughput

0.489

High

360280

COX1
Cytochrome c oxidase subunit 1

1

3

High-throughput

0.489

High

664986

ERD21
ER lumen protein-retaining receptor 1

1

8

High-throughput

0.489

High

697419

DCK
Deoxycytidine kinase

1

1

High-throughput

0.489

High

749617

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

3

High-throughput

0.489

High

941927

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.489

High

944512

GEMI4
Gem-associated protein 4

1

5

High-throughput

0.489

High

1041675

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

6

High-throughput

0.489

High

1141506

OXA1L
Mitochondrial inner membrane protein OXA1L

1

4

High-throughput

0.489

High

1164455

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.489

High

1203375

YIF1B
Protein YIF1B

1

6

High-throughput

0.489

High

1204986

RABL3
Rab-like protein 3

1

6

High-throughput

0.489

High

1209965

TM201
Transmembrane protein 201

1

2

High-throughput

0.489

High

1211774

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

5

High-throughput

0.489

High

1218422

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.489

High

1219289

ECM29
Proteasome adapter and scaffold protein ECM29

1

20

High-throughput

0.489

High

1231435

ATLA3
Atlastin-3

1

14

High-throughput

0.489

High

1239231

ARMC6
Armadillo repeat-containing protein 6

1

4

High-throughput

0.489

High

1242073

TTC27
Tetratricopeptide repeat protein 27

1

5

High-throughput

0.489

High

1244349

SKI3
Superkiller complex protein 3

1

2

High-throughput

0.489

High

1251531

THADA
tRNA

1

7

High-throughput

0.489

High

1272928

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

20

High-throughput

0.489

High

1275361

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

8

High-throughput

0.489

High

1275932

SETX
Probable helicase senataxin

1

1

High-throughput

0.489

High

1277490

MON2
Protein MON2 homolog

1

20

High-throughput

0.489

High

1288623

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

8

High-throughput

0.489

High

1291833

CNDG2
Condensin-2 complex subunit G2

1

2

High-throughput

0.489

High

1291836

ZDH17
Palmitoyltransferase ZDHHC17

1

8

High-throughput

0.489

High

1291837

K2013
Uncharacterized protein KIAA2013

1

9

High-throughput

0.489

High

1291839

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

6

High-throughput

0.489

High

1291843

ZNT7
Zinc transporter 7

1

15

High-throughput

0.489

High

1291849

TM9S4
Transmembrane 9 superfamily member 4

1

14

High-throughput

0.489

High

1291850

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

9

High-throughput

0.489

High

1291851

GCN1
Stalled ribosome sensor GCN1

1

20

High-throughput

0.489

High

1291852

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.489

High

1291853

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

1291854

YIPF5
Protein YIPF5

1

8

High-throughput

0.489

High

1291857

EVI5L
EVI5-like protein

1

9

High-throughput

0.489

High

1291858

F241B
Protein FAM241B

1

4

High-throughput

0.489

High

1291861

SAAL1
Protein SAAL1

1

3

High-throughput

0.489

High

1291862

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

4

High-throughput

0.489

High

1291865

RN185
E3 ubiquitin-protein ligase RNF185

1

8

High-throughput

0.489

High

1291869

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

9

High-throughput

0.489

High

1291870

CP2S1
Cytochrome P450 2S1

1

3

High-throughput

0.489

High

1291872

SEC62
Translocation protein SEC62

1

3

High-throughput

0.489

High

1291875

SGMR1
Sigma non-opioid intracellular receptor 1

1

6

High-throughput

0.489

High

1291877

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.489

High

1291879

GCP2
Gamma-tubulin complex component 2

1

18

High-throughput

0.489

High

1291880

DERL1
Derlin-1

1

6

High-throughput

0.489

High

1291881

PTSS2
Phosphatidylserine synthase 2

1

10

High-throughput

0.489

High

1291882

SYTM
Threonine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

1291886

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

High-throughput

0.489

High

1291887

XPO4
Exportin-4

1

20

High-throughput

0.489

High

1291889

DERL2
Derlin-2

1

6

High-throughput

0.489

High

1291890

INT2
Integrator complex subunit 2

1

4

High-throughput

0.489

High

1291893

SPNS1
Protein spinster homolog 1

1

2

High-throughput

0.489

High

1291897

HEAT1
HEAT repeat-containing protein 1

1

6

High-throughput

0.489

High

1291898

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

3

High-throughput

0.489

High

1291900

COG4
Conserved oligomeric Golgi complex subunit 4

1

5

High-throughput

0.489

High

1291904

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.489

High

1291907

ECHD1
Ethylmalonyl-CoA decarboxylase

1

6

High-throughput

0.489

High

1291908

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

13

High-throughput

0.489

High

1291909

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

6

High-throughput

0.489

High

1291911

FANCI
Fanconi anemia group I protein

1

2

High-throughput

0.489

High

1291915

FA8A1
Protein FAM8A1

1

1

High-throughput

0.489

High

1291918

IPO11
Importin-11

1

20

High-throughput

0.489

High

1291920

TMCO1
Calcium load-activated calcium channel

1

6

High-throughput

0.489

High

1291921

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

4

High-throughput

0.489

High

1291924

C2CD2
C2 domain-containing protein 2

1

1

High-throughput

0.489

High

1291925

TELO2
Telomere length regulation protein TEL2 homolog

1

4

High-throughput

0.489

High

1291928

TNPO3
Transportin-3

1

20

High-throughput

0.489

High

1291929

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

7

High-throughput

0.489

High

1291930

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

20

High-throughput

0.489

High

157571

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.481

High

1286428

DSG4
Desmoglein-4

1

3

High-throughput

0.479

High

1291884

HYCCI
Hyccin

1

2

High-throughput

0.479

High

168865

PLD2
Phospholipase D2

1

4

High-throughput

0.445

High

296920

DGAT1
Diacylglycerol O-acyltransferase 1

1

4

High-throughput

0.445

High

722512

CTR1
High affinity cationic amino acid transporter 1

1

10

High-throughput

0.445

High

839475

PI4KA
Phosphatidylinositol 4-kinase alpha

1

19

High-throughput

0.445

High

897587

KNTC1
Kinetochore-associated protein 1

1

5

High-throughput

0.445

High

1090065

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

7

High-throughput

0.445

High

1122023

EFR3A
Protein EFR3 homolog A

1

1

High-throughput

0.445

High

1291841

TM87A
Transmembrane protein 87A

1

8

High-throughput

0.445

High

1291867

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

10

High-throughput

0.445

High

1291892

S38A1
Sodium-coupled neutral amino acid symporter 1

1

4

High-throughput

0.445

High

1195661

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

17

High-throughput

0.437

High

1291913

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

7

High-throughput

0.437

High

220609

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

1291902

PGAP6
Post-GPI attachment to proteins factor 6

1

0

High-throughput

0.426

High

1291927

PCDGD
Protocadherin gamma-B1

1

0

High-throughput

0.426

High

252878

EXOC3
Exocyst complex component 3

1

6

High-throughput

0.407

High

404183

GCR
Glucocorticoid receptor

1

6

High-throughput

0.407

High

942500

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

5

High-throughput

0.407

High

1085337

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

8

High-throughput

0.407

High

1119444

CASP
Protein CASP

1

8

High-throughput

0.407

High

1228871

ZFY26
Zinc finger FYVE domain-containing protein 26

1

7

High-throughput

0.407

High

1278604

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.407

High

1287233

ATL2
ADAMTS-like protein 2

1

1

High-throughput

0.407

High

1291847

RUFY2
RUN and FYVE domain-containing protein 2

1

8

High-throughput

0.407

High

1291855

VP33A
Vacuolar protein sorting-associated protein 33A

1

4

High-throughput

0.407

High

1291856

INT12
Integrator complex subunit 12

1

5

High-throughput

0.407

High

1291871

RUFY1
RUN and FYVE domain-containing protein 1

1

8

High-throughput

0.407

High

1291876

MICU1
Calcium uptake protein 1, mitochondrial

1

4

High-throughput

0.407

High

1291896

SMOC1
SPARC-related modular calcium-binding protein 1

1

3

High-throughput

0.407

High

1291901

EPG5
Ectopic P granules protein 5 homolog

1

1

High-throughput

0.407

High

1291910

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

3

High-throughput

0.407

High

270021

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.279

Low

1061339

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

1083187

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1276403

GLUCM
D-glutamate cyclase, mitochondrial

1

0

High-throughput

0.279

Low

1291842

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.279

Low

1291863

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.279

Low

1291917

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

1291926

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.279

Low

187372

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.232

Low

1149592

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.232

Low

1291931

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025