HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 26496610, 28514442, 28292943, 33961781, 20810900, 17353931, 23212908, 35271311, 21628461, 22275368, 19490896, unassigned3799
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation, cosedimentation in solution, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB_C, AAA_lid_3~AAA_lid_3, Prot_ATP_ID_OB_C~Prot_ATP_ID_OB_C
Common GO terms GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 6 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 418
Hs

1 440
+ At
+ At
+ At
+ At
+ Dm
+ Hs
+ Hs
+ Hs
+ At
+ At
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm

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Last updated: 11Aug2025