HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	35271311, 21900206
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 192
+	Hs
		854769 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Mm
		925816 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71
+	Hs
		545278 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Mm
		892716 GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06		RAC3_MOUSE (1-192): 5.54e-79: 235: 100.00
+	Hs
		854771 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		854760 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Rn
		901290 GDIR1_RAT (1-204): 6.26e-117: 332: 97.06		RHOA_RAT (5-192): 9.79e-77: 229: 54.79
+	Hs
		854763 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436218 GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		854851 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		925561 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545279 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Mm
		892713 GDIR2_MOUSE (13-204): 1.25e-98: 285: 68.75		RAC3_MOUSE (1-192): 5.54e-79: 235: 100.00
+	Hs
		854847 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		854852 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		951270 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		894357 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900840 GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	At
		1105170 GDIR_ARATH (2-202): 4.35e-89: 263: 37.86		RAC5_ARATH (4-177): 1.21e-78: 234: 64.37
+	At
		1105129 GDIR_ARATH (2-202): 4.35e-89: 263: 37.86		RAC3_ARATH (2-192): 1.26e-73: 221: 60.20