Protein: ULP1
Ubiquitin-like-specific protease 1 (EC 3.4.22.68)

Gene: ULP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 218
UniProt ID: Q02724

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005730 - nucleolus
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038124

SMT3
Ubiquitin-like protein SMT3

8

20

Small-scale

0.971

High

734718

IMB3
Importin subunit beta-3

7

6

Small-scale

0.751

High

1038089

IMA1
Importin subunit alpha

8

4

Small-scale

0.749

High

1038105

IMB1
Importin subunit beta-1

7

6

Small-scale

0.743

High

1038088

ULP1
Ubiquitin-like-specific protease 1

1

3

Small-scale

0.647

High

782551

NU133
Nucleoporin NUP133

2

1

High-throughput

0.586

High

818694

GPP2
Glycerol-1-phosphate phosphohydrolase 2

2

1

High-throughput

0.586

High

1038095

GLRX3
Monothiol glutaredoxin-3

2

4

High-throughput

0.586

High

524904

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.576

High

652895

TRX2
Thioredoxin-2

2

2

High-throughput

0.576

High

672609

YCP7
DUP240 protein DFP3

2

2

High-throughput

0.539

High

1038094

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.537

High

819570

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.536

High

454229

LEUC
3-isopropylmalate dehydratase

2

2

High-throughput

0.535

High

1038125

GLE1
mRNA export factor GLE1

1

0

Small-scale

0.529

High

579929

HSC82
ATP-dependent molecular chaperone HSC82

2

4

High-throughput

0.526

High

812926

UIP3
ULP1-interacting protein 3

1

2

High-throughput

0.508

High

359053

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

5

High-throughput

0.481

High

359324

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

5

High-throughput

0.481

High

364703

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.481

High

366661

ARGI
Arginase

1

1

High-throughput

0.481

High

366834

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.481

High

527480

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.481

High

547824

NHP6A
Non-histone chromosomal protein 6A

1

4

High-throughput

0.481

High

547884

NHP6B
Non-histone chromosomal protein 6B

1

5

High-throughput

0.481

High

548720

RNA1
Ran GTPase-activating protein 1

1

3

High-throughput

0.481

High

575993

CYPH
Peptidyl-prolyl cis-trans isomerase

1

4

High-throughput

0.481

High

576073

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

2

High-throughput

0.481

High

584415

KGUA
Guanylate kinase

1

1

High-throughput

0.481

High

584453

IDI1
Isopentenyl-diphosphate delta-isomerase

1

1

High-throughput

0.481

High

585511

KCY
Uridylate kinase

1

2

High-throughput

0.481

High

607470

GLRX2
Glutaredoxin-2

1

1

High-throughput

0.481

High

633267

CKS1
Cyclin-dependent kinases regulatory subunit

1

1

High-throughput

0.481

High

646076

KIN3
Serine/threonine-protein kinase KIN3

1

2

High-throughput

0.481

High

646613

TRX1
Thioredoxin-1

1

2

High-throughput

0.481

High

649517

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.481

High

671041

SIS1
Protein SIS1

1

2

High-throughput

0.481

High

700041

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.481

High

709937

BMH1
Protein BMH1

1

1

High-throughput

0.481

High

725894

CYS3
Cystathionine gamma-lyase

1

1

High-throughput

0.481

High

726175

2AAA
Protein phosphatase PP2A regulatory subunit A

1

1

High-throughput

0.481

High

736799

AROG
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

1

2

High-throughput

0.481

High

743273

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.481

High

776307

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.481

High

781997

SHB17
Sedoheptulose 1,7-bisphosphatase

1

2

High-throughput

0.481

High

802829

GRE3
NADPH-dependent aldose reductase GRE3

1

2

High-throughput

0.481

High

806494

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.481

High

806945

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

1

High-throughput

0.481

High

807127

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.481

High

813392

NPT1
Nicotinate phosphoribosyltransferase

1

1

High-throughput

0.481

High

834722

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.481

High

844391

SERB
Phosphoserine phosphatase

1

2

High-throughput

0.481

High

886174

NUP42
Nucleoporin NUP42

1

1

Small-scale

0.481

High

912379

UBA2
Ubiquitin-activating enzyme E1-like

1

2

High-throughput

0.481

High

915245

ACS2
Acetyl-coenzyme A synthetase 2

1

2

High-throughput

0.481

High

923773

HCH1
Hsp90 co-chaperone HCH1

1

2

High-throughput

0.481

High

924596

YNN4
Uncharacterized protein YNL134C

1

1

High-throughput

0.481

High

932653

ERG13
Hydroxymethylglutaryl-CoA synthase

1

1

High-throughput

0.481

High

1026807

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.481

High

1038034

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

1

High-throughput

0.481

High

1038100

HNT1
Adenosine 5'-monophosphoramidase HNT1

1

1

High-throughput

0.481

High

1038103

ADH6
NADP-dependent alcohol dehydrogenase 6

1

2

High-throughput

0.481

High

1038106

TMA10
Translation machinery-associated protein 10

1

1

High-throughput

0.481

High

1038107

FKBP4
FK506-binding protein 4

1

3

High-throughput

0.481

High

1038108

BCP1
Protein BCP1

1

1

High-throughput

0.481

High

1038113

KAR
NADPH-dependent alpha-keto amide reductase

1

3

High-throughput

0.481

High

1038117

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

1

High-throughput

0.481

High

1038120

PUS1
tRNA pseudouridine synthase 1

1

1

High-throughput

0.481

High

1038121

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.481

High

1038126

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.481

High

1038127

YPR1
Aldehyde reductase YPR1

1

2

High-throughput

0.481

High

1038132

YD85C
SERF-like protein YDL085C-A

1

1

High-throughput

0.481

High

382294

H4
Histone H4

1

2

High-throughput

0.479

High

459150

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

634271

NUP1
Nucleoporin NUP1

1

3

High-throughput

0.479

High

673121

RNQ1
[PIN+] prion protein RNQ1

1

1

High-throughput

0.479

High

707957

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

722189

XPO1
Exportin-1

1

1

High-throughput

0.479

High

738502

NUP2
Nucleoporin NUP2

1

7

High-throughput

0.479

High

738909

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

740210

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.479

High

740748

SRP40
Suppressor protein SRP40

1

1

High-throughput

0.479

High

741072

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

795164

NU170
Nucleoporin NUP170

1

2

High-throughput

0.479

High

801732

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.479

High

823023

ATAD2
ATPase histone chaperone YTA7

1

2

High-throughput

0.479

High

824774

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

850617

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

2

High-throughput

0.479

High

921594

CAN
Carbonic anhydrase

1

1

High-throughput

0.479

High

963662

H3
Histone H3

1

6

High-throughput

0.479

High

1038099

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.479

High

1038116

MDN1
Midasin

1

1

High-throughput

0.479

High

1038128

YB11B
Transposon Ty1-BL Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1038131

RRP12
Ribosomal RNA-processing protein 12

1

1

High-throughput

0.479

High

917978

PRM8
Pheromone-regulated membrane protein 8

1

2

High-throughput

0.464

High

361450

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.460

High

454047

GCR1
Glycolytic genes transcriptional activator GCR1

1

0

High-throughput

0.460

High

597754

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.460

High

639509

RE107
Recombination protein 107

1

0

High-throughput

0.460

High

651981

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.460

High

693519

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.460

High

749713

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

780380

ELF1
Transcription elongation factor 1

1

0

High-throughput

0.460

High

795838

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.460

High

796353

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

813303

FHP
Flavohemoprotein

1

0

High-throughput

0.460

High

817453

RGI1
Respiratory growth induced protein 1

1

0

High-throughput

0.460

High

825073

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.460

High

826313

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.460

High

834789

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.460

High

865609

DOHH
Deoxyhypusine hydroxylase

1

0

High-throughput

0.460

High

866017

ADK
Adenosine kinase

1

0

High-throughput

0.460

High

866058

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

883389

APT1
Adenine phosphoribosyltransferase 1

1

0

High-throughput

0.460

High

912433

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.460

High

924575

ADE
Adenine deaminase

1

0

High-throughput

0.460

High

925489

PYP1
Polyol phosphate phosphatase PYP1

1

0

High-throughput

0.460

High

1036167

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.460

High

1038091

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.460

High

1038102

YMW4
Uncharacterized protein YMR074C

1

0

High-throughput

0.460

High

1038110

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

1038111

TSR2
Pre-rRNA-processing protein TSR2

1

0

High-throughput

0.460

High

1038129

TMA17
Translation machinery-associated protein 17

1

0

High-throughput

0.460

High

1038134

IGO2
mRNA stability protein IGO2

1

0

High-throughput

0.460

High

464337

OAT
Ornithine aminotransferase

1

0

High-throughput

0.458

High

748009

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

782676

ESL2
EST/SMG-like protein 2

1

0

High-throughput

0.458

High

813650

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.458

High

849945

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.458

High

865714

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

1038097

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1038118

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

545973

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

742222

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

365683

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.439

High

367800

ENO1
Enolase 1

1

4

High-throughput

0.439

High

368036

ENO2
Enolase 2

1

4

High-throughput

0.439

High

368735

PMG1
Phosphoglycerate mutase 1

1

2

High-throughput

0.439

High

383183

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.439

High

450743

KAD2
Adenylate kinase

1

2

High-throughput

0.439

High

513554

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.439

High

599668

STF2
ATPase-stabilizing factor 15 kDa protein

1

1

High-throughput

0.439

High

621400

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.439

High

691615

AP2B
AP-2 complex subunit beta

1

4

High-throughput

0.439

High

702230

CWP1
Cell wall protein CWP1

1

1

High-throughput

0.439

High

732183

COPG
Coatomer subunit gamma

1

3

High-throughput

0.439

High

735659

SMY1
Kinesin-related protein SMY1

1

2

High-throughput

0.439

High

748771

YPT7
Ypt/Rab-type GTPase YPT7

1

1

High-throughput

0.439

High

757864

PTH2
Peptidyl-tRNA hydrolase 2

1

1

High-throughput

0.439

High

763258

SQT1
Ribosome assembly protein SQT1

1

8

High-throughput

0.439

High

775984

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.439

High

779631

VPS21
Vacuolar protein sorting-associated protein 21

1

1

High-throughput

0.439

High

790221

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.439

High

792369

AHP1
Peroxiredoxin AHP1

1

1

High-throughput

0.439

High

793345

SYG
Glycine--tRNA ligase 1, mitochondrial

1

1

High-throughput

0.439

High

802968

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.439

High

886202

NU145
Nucleoporin NUP145

1

5

High-throughput

0.439

High

922681

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

5

High-throughput

0.439

High

925234

MTQ1
Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1

1

1

High-throughput

0.439

High

1038093

YM8V
Uncharacterized protein YMR295C

1

1

High-throughput

0.439

High

1038115

YP225
Protein PBDC1 homolog

1

1

High-throughput

0.439

High

1038123

RDL1
Thiosulfate:glutathione sulfurtransferase

1

2

High-throughput

0.439

High

438477

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.437

High

557627

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

3

High-throughput

0.437

High

738423

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

739733

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.437

High

763486

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.437

High

779569

LHS1
Heat shock protein 70 homolog LHS1

1

7

Small-scale

0.437

High

796616

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.437

High

805306

GGA2
ADP-ribosylation factor-binding protein GGA2

1

1

High-throughput

0.437

High

817567

SERA
D-3-phosphoglycerate dehydrogenase 1

1

1

High-throughput

0.437

High

850337

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

9

High-throughput

0.437

High

925478

EF3B
Elongation factor 3B

1

3

High-throughput

0.437

High

1038114

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.437

High

1038119

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

1

High-throughput

0.437

High

1038130

YP015
Zinc finger protein YPR015C

1

3

High-throughput

0.437

High

1038096

TVP15
Golgi apparatus membrane protein TVP15

2

0

High-throughput

0.307

High

800357

GRPE
GrpE protein homolog, mitochondrial

2

0

High-throughput

0.306

High

453755

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.279

Low

1038092

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.265

Low

1038101

TVP18
Golgi apparatus membrane protein TVP18

1

0

High-throughput

0.265

Low

1038122

TM115
Transmembrane protein 115 homolog

1

0

High-throughput

0.265

Low

737025

CDC3
Cell division control protein 3

1

0

Small-scale

0.261

Low

368478

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.251

Low

432354

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.251

Low

515381

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.251

Low

572638

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.251

Low

673073

OCA4
Protein OCA4

1

0

High-throughput

0.251

Low

701638

PYRD
Dihydroorotate dehydrogenase

1

0

High-throughput

0.251

Low

713512

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.251

Low

753129

NIP80
Protein NIP100

1

0

High-throughput

0.251

Low

776708

ASK1
DASH complex subunit ASK1

1

0

High-throughput

0.251

Low

781915

SPC34
DASH complex subunit SPC34

1

0

High-throughput

0.251

Low

802528

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.251

Low

803306

ETP1
RING finger protein ETP1

1

0

High-throughput

0.251

Low

807201

IF1A
Eukaryotic translation initiation factor 1A

1

0

High-throughput

0.251

Low

836584

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.251

Low

858392

STU2
Protein STU2

1

0

High-throughput

0.251

Low

918663

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.251

Low

922980

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.251

Low

999572

DAD3
DASH complex subunit DAD3

1

0

High-throughput

0.251

Low

1038090

COFI
Cofilin

1

0

High-throughput

0.251

Low

1038104

HOR7
Protein HOR7

1

0

High-throughput

0.251

Low

538348

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.249

Low

737112

CDC11
Cell division control protein 11

1

0

Small-scale

0.249

Low

751713

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.249

Low

779438

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

789812

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

793137

YRO2
Protein YRO2

1

0

High-throughput

0.249

Low

803216

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.249

Low

850535

PTR3
SPS-sensor component PTR3

1

0

High-throughput

0.249

Low

863616

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

High-throughput

0.249

Low

1026964

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.249

Low

1038098

YHM2
Citrate/oxoglutarate carrier protein

1

0

High-throughput

0.249

Low

1038109

YP148
Uncharacterized protein YPR148C

1

0

High-throughput

0.249

Low

1038133

YO019
Uncharacterized protein YOR019W

1

0

High-throughput

0.249

Low

1038112

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025