Protein: SENP2
Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)

Gene: SENP2
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q9HC62

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

939232

SUMO3
Small ubiquitin-related modifier 3

5

20

Small-scale

0.938

High

991434

SUMO1
Small ubiquitin-related modifier 1

4

20

Small-scale

0.888

High

964462

SUMO2
Small ubiquitin-related modifier 2

3

20

Small-scale

0.877

High

854745

RAGP1
Ran GTPase-activating protein 1

2

3

Small-scale

0.778

High

890402

NU153
Nuclear pore complex protein Nup153

3

8

Small-scale

0.664

High

1438713

NEMO
NF-kappa-B essential modulator

2

1

Small-scale

0.660

High

1338975

NUP43
Nucleoporin Nup43

3

10

High-throughput

0.640

High

451706

PGK2
Phosphoglycerate kinase 2

2

1

High-throughput

0.628

High

1402014

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

2

6

High-throughput

0.628

High

965895

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

0

Small-scale

0.622

High

945313

NU107
Nuclear pore complex protein Nup107

2

1

High-throughput

0.611

High

1325563

RDHE2
Epidermal retinol dehydrogenase 2

2

1

High-throughput

0.606

High

423218

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

987479

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.586

High

634646

LMNB1
Lamin-B1

2

8

Small-scale

0.584

High

951442

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

922783

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.580

High

1214859

ARM12
Armadillo repeat-containing protein 12

2

0

High-throughput

0.580

High

821582

TCPZ
T-complex protein 1 subunit zeta

2

0

Small-scale

0.576

High

1144315

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.561

High

1438708

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.561

High

417770

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

Small-scale

0.559

High

1386085

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

1

High-throughput

0.553

High

1139277

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.549

High

407715

S100B
Protein S100-B

1

4

High-throughput

0.536

High

1390540

CDCA5
Sororin

1

0

High-throughput

0.518

High

1402906

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.518

High

186038

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

373198

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.501

High

520385

ANDR
Androgen receptor

1

5

Small-scale

0.501

High

911388

IMA5
Importin subunit alpha-5

1

4

Small-scale

0.501

High

1042928

ERCC6
DNA excision repair protein ERCC-6

1

4

High-throughput

0.501

High

1134392

IMB1
Importin subunit beta-1

1

5

Small-scale

0.501

High

1380858

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.501

High

1400024

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

3

High-throughput

0.501

High

1401284

NACC1
Nucleus accumbens-associated protein 1

1

7

Small-scale

0.501

High

1438703

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.501

High

302969

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

7

High-throughput

0.489

High

386254

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.481

High

48803

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

126812

RHOD
Rho-related GTP-binding protein RhoD

1

15

High-throughput

0.479

High

138772

IMA4
Importin subunit alpha-4

1

4

Small-scale

0.479

High

142622

IMA3
Importin subunit alpha-3

1

4

Small-scale

0.479

High

159867

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

220664

SYT7
Synaptotagmin-7

1

1

Small-scale

0.479

High

221809

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.479

High

291548

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

341680

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

446052

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

457717

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

466471

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

515851

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

1

Small-scale

0.479

High

537938

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

581302

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

604220

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

611362

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

618739

ML12A
Myosin regulatory light chain 12A

1

1

Small-scale

0.479

High

630981

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

714437

PML
Protein PML

1

7

High-throughput

0.479

High

754991

H2B1B
Histone H2B type 1-B

1

5

Small-scale

0.479

High

860613

RS5
Small ribosomal subunit protein uS7

1

1

Small-scale

0.479

High

895072

EMD
Emerin

1

1

High-throughput

0.479

High

899243

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.479

High

899592

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.479

High

902086

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

911115

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.479

High

955619

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

962510

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

965258

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.479

High

980359

H4
Histone H4

1

2

Small-scale

0.479

High

983058

RS25
Small ribosomal subunit protein eS25

1

1

Small-scale

0.479

High

996345

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

1015804

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1045790

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1087295

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1129755

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.479

High

1145120

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

1155791

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1250667

BCOR
BCL-6 corepressor

1

3

High-throughput

0.479

High

1251350

DJC14
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.479

High

1252237

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1290319

MORC1
MORC family CW-type zinc finger protein 1

1

1

Small-scale

0.479

High

1295720

HORN
Hornerin

1

4

Small-scale

0.479

High

1334007

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1336757

RB15B
Putative RNA-binding protein 15B

1

3

High-throughput

0.479

High

1356940

NU133
Nuclear pore complex protein Nup133

1

1

High-throughput

0.479

High

1395952

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1401094

H2A1A
Histone H2A type 1-A

1

3

Small-scale

0.479

High

1414458

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1432271

HIPK2
Homeodomain-interacting protein kinase 2

1

2

Small-scale

0.479

High

1436316

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1438697

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1438704

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1438705

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

6

Small-scale

0.479

High

1438710

RUVB2
RuvB-like 2

1

2

Small-scale

0.479

High

1438711

ST38L
Serine/threonine-protein kinase 38-like

1

1

Small-scale

0.479

High

337972

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

369507

AACT
Alpha-1-antichymotrypsin

1

0

Small-scale

0.458

High

387466

APOE
Apolipoprotein E

1

0

Small-scale

0.458

High

699148

CALX
Calnexin

1

0

High-throughput

0.458

High

837850

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

880704

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

904129

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

948475

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.458

High

952651

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.458

High

953114

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

976576

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

999410

HBB
Hemoglobin subunit beta

1

0

Small-scale

0.458

High

1004208

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1007290

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.458

High

1010719

DCD
Dermcidin

1

0

Small-scale

0.458

High

1153918

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1160587

SMN
Survival motor neuron protein

1

0

Small-scale

0.458

High

1229091

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1339182

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1401707

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1409896

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

1421142

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1438694

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1438700

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1438706

ADA28
Disintegrin and metalloproteinase domain-containing protein 28

1

0

Small-scale

0.458

High

1438712

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

62305

SH321
SH3 domain-containing protein 21

1

2

Small-scale

0.437

High

189856

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

847700

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

996863

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.437

High

1058669

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.437

High

1151885

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.437

High

1242096

TTC27
Tetratricopeptide repeat protein 27

1

1

Small-scale

0.437

High

1322998

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1382946

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1383089

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.437

High

1404220

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1410926

SYT15
Synaptotagmin-15

1

1

Small-scale

0.437

High

1412674

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.437

High

1431253

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1438695

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1438698

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1438699

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

251657

CCNT1
Cyclin-T1

1

0

High-throughput

0.426

High

1247416

ATRAP
Type-1 angiotensin II receptor-associated protein

3

0

High-throughput

0.352

High

1329442

KASH5
Protein KASH5

3

0

High-throughput

0.352

High

1359040

TM239
Transmembrane protein 239

3

0

High-throughput

0.352

High

933987

APOC4
Apolipoprotein C-IV

2

0

High-throughput

0.316

High

1291502

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

1438696

RPRM
Protein reprimo

2

0

High-throughput

0.316

High

1438702

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.316

High

1309034

FUND1
FUN14 domain-containing protein 1

1

0

High-throughput

0.299

High

1323886

SYNE4
Nesprin-4

1

0

High-throughput

0.299

High

1438707

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

387635

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.251

Low

938077

TPD52
Tumor protein D52

1

0

High-throughput

0.251

Low

106675

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

174099

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.249

Low

418444

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

626057

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

0

Small-scale

0.249

Low

1027188

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1111713

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

1293159

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1401232

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1431753

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1436753

GHC1
Mitochondrial glutamate carrier 1

1

0

Small-scale

0.249

Low

1438701

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1438709

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025