HitPredict

Interactor 1: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Interactor 2: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, STAT_alpha~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 851 Hs			1 987
+	Hs
		776626 STAT3_HUMAN (1-747): 0: 846: 37.47		EPHA5_HUMAN (1-978): 0: 1099: 47.77
+	Hs
		849879 STA5B_HUMAN (1-768): 0: 774: 24.67		EPHA4_HUMAN (3-981): 0: 1093: 49.70
+	Rn
		94369 F1M9D6_RAT (1-730): 0: 882: 42.71		INSR_RAT (380-879): 6.3e-136: 444: 30.43
+	Mm
		786524 STAT3_MOUSE (1-747): 0: 846: 37.47		TIE2_MOUSE (323-883): 5.03e-145: 462: 25.26
+	Hs
		411328 STAT3_HUMAN (1-747): 0: 846: 37.47		INSR_HUMAN (380-879): 9.63e-136: 443: 29.65
+	Hs
		435568 STAT3_HUMAN (1-747): 0: 846: 37.47		IGF1R_HUMAN (390-876): 1.79e-133: 437: 28.00
+	Hs
		411330 STA5A_HUMAN (1-769): 0: 789: 24.67		INSR_HUMAN (380-879): 9.63e-136: 443: 29.65
+	Hs
		411341 STA5B_HUMAN (1-768): 0: 774: 24.67		INSR_HUMAN (380-879): 9.63e-136: 443: 29.65
+	Hs
		786322 STAT1_HUMAN (1-728): 0: 879: 42.36		FAK1_HUMAN (595-878): 1.01e-61: 230: 41.55
+	Hs
		776657 STAT3_HUMAN (1-747): 0: 846: 37.47		FAK1_HUMAN (595-878): 1.01e-61: 230: 41.55
+	Hs
		442788 STAT3_HUMAN (1-747): 0: 846: 37.47		HCK_HUMAN (593-875): 8.85e-63: 224: 41.55