Protein: WDFY3
WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)

Gene: WDFY3
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q8IZQ1

Gene Ontology (top 5):
GO:0000421 - autophagosome membrane
GO:0005545 - 1-phosphatidylinositol binding
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161731

APAF
Apoptotic protease-activating factor 1

2

14

High-throughput

0.811

High

821741

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

1

High-throughput

0.811

High

1066238

DMWD
Dystrophia myotonica WD repeat-containing protein

2

17

High-throughput

0.811

High

1153192

HERC1
Probable E3 ubiquitin-protein ligase HERC1

2

10

High-throughput

0.811

High

1202203

DCAF6
DDB1- and CUL4-associated factor 6

2

18

High-throughput

0.811

High

638468

FPR1
fMet-Leu-Phe receptor

2

6

High-throughput

0.776

High

1101577

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

8

High-throughput

0.776

High

1142503

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.770

High

1107914

SQSTM
Sequestosome-1

4

3

Small-scale

0.704

High

133276

P2Y10
Putative P2Y purinoceptor 10

1

10

High-throughput

0.691

High

165985

FFAR1
Free fatty acid receptor 1

1

7

High-throughput

0.691

High

182650

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.691

High

867639

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.691

High

867984

GLR
Glucagon receptor

1

2

High-throughput

0.691

High

880173

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.691

High

1316750

NEDD1
Protein NEDD1

1

15

High-throughput

0.691

High

1316790

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.691

High

568070

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

3

High-throughput

0.667

High

1227038

A16L1
Autophagy-related protein 16-1

1

14

Small-scale

0.665

High

1316758

H2B1H
Histone H2B type 1-H

1

10

High-throughput

0.665

High

216485

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.656

High

832427

OPRX
Nociceptin receptor

1

0

High-throughput

0.656

High

1316768

MLP3B
Microtubule-associated protein 1 light chain 3 beta

3

20

Small-scale

0.656

High

1316774

TRI39
E3 ubiquitin-protein ligase TRIM39

2

2

High-throughput

0.640

High

328068

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

20

Small-scale

0.634

High

427914

ICAM1
Intercellular adhesion molecule 1

2

2

High-throughput

0.628

High

1252588

DEFI8
Differentially expressed in FDCP 8 homolog

2

1

High-throughput

0.628

High

1309687

WDR75
WD repeat-containing protein 75

2

16

High-throughput

0.628

High

1312180

MIRO2
Mitochondrial Rho GTPase 2

2

20

High-throughput

0.628

High

1316752

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

2

High-throughput

0.628

High

1316754

DC2I1
Cytoplasmic dynein 2 intermediate chain 1

2

10

High-throughput

0.628

High

1316762

DDX11
ATP-dependent DNA helicase DDX11

2

2

High-throughput

0.628

High

1316756

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

6

High-throughput

0.628

High

1254586

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1316772

ATG5
Autophagy protein 5

1

2

Small-scale

0.602

High

1316748

FLCN
Folliculin

2

0

High-throughput

0.602

High

1316782

P2RX2
P2X purinoceptor 2

2

0

High-throughput

0.602

High

774486

BASI
Basigin

2

8

High-throughput

0.601

High

1316767

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

20

Small-scale

0.597

High

827842

STAT3
Signal transducer and activator of transcription 3

2

1

High-throughput

0.594

High

987767

GRB2
Growth factor receptor-bound protein 2

2

8

High-throughput

0.594

High

952240

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

Small-scale

0.589

High

1233684

Q6IAW1
Epididymis secretory sperm binding protein

1

20

Small-scale

0.589

High

1316770

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

Small-scale

0.589

High

1316773

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

20

Small-scale

0.584

High

1316788

TRAF6
TNF receptor-associated factor 6

2

6

Small-scale

0.584

High

1224858

TENS2
Tensin-2

2

4

High-throughput

0.576

High

1316764

OPALI
Opalin

2

0

High-throughput

0.576

High

754061

CD80
T-lymphocyte activation antigen CD80

1

6

High-throughput

0.575

High

1291838

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

8

High-throughput

0.575

High

1316787

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

7

High-throughput

0.575

High

1316746

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.573

High

380089

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

3

High-throughput

0.552

High

1316751

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.549

High

704040

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.546

High

155864

DPYL4
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.536

High

619853

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.536

High

686837

S10A4
Protein S100-A4

1

4

High-throughput

0.536

High

688589

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.536

High

719027

WEE1
Wee1-like protein kinase

1

7

High-throughput

0.536

High

856792

BAG6
Large proline-rich protein BAG6

1

13

High-throughput

0.536

High

900912

RAB5C
Ras-related protein Rab-5C

1

15

High-throughput

0.536

High

1126856

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

7

High-throughput

0.536

High

1316761

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

10

High-throughput

0.536

High

1316779

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.536

High

1123515

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

1316760

OPTN
Optineurin

1

14

High-throughput

0.515

High

1293861

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

7

High-throughput

0.514

High

134451

EF2K
Eukaryotic elongation factor 2 kinase

1

0

High-throughput

0.513

High

486586

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

488822

FURIN
Furin

1

0

High-throughput

0.513

High

723938

LCN1
Lipocalin-1

1

0

High-throughput

0.513

High

843749

HD
Huntingtin

1

0

Small-scale

0.513

High

1175811

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

1316743

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1316755

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1316771

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

1316781

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

1316783

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

1316763

ANM6
Protein arginine N-methyltransferase 6

1

7

High-throughput

0.508

High

1316766

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.508

High

317655

ATG12
Ubiquitin-like protein ATG12

1

0

Small-scale

0.493

High

47371

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

848521

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.489

High

1316744

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

High-throughput

0.489

High

1316775

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

3

High-throughput

0.489

High

1316765

MDFI
MyoD family inhibitor

1

0

High-throughput

0.486

High

174552

TRI66
Tripartite motif-containing protein 66

1

8

High-throughput

0.479

High

347801

BAG3
BAG family molecular chaperone regulator 3

1

5

High-throughput

0.479

High

372542

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

404213

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

976403

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

990481

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1276210

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1316780

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.479

High

1316785

XPO7
Exportin-7

1

17

High-throughput

0.479

High

1316789

TRI17
E3 ubiquitin-protein ligase TRIM17

1

2

Small-scale

0.479

High

1316747

MFI
Protein MFI

1

0

High-throughput

0.458

High

1208985

RBG1L
Rab GTPase-activating protein 1-like

1

1

High-throughput

0.451

High

50615

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

139263

UPK2
Uroplakin-2

1

2

High-throughput

0.445

High

230986

TYOBP
TYRO protein tyrosine kinase-binding protein

1

1

High-throughput

0.445

High

538781

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.445

High

791523

SYUA
Alpha-synuclein

1

2

Small-scale

0.445

High

1010946

BAT1
b(0,+)-type amino acid transporter 1

1

6

High-throughput

0.445

High

1057687

TNR9
Tumor necrosis factor receptor superfamily member 9

1

8

High-throughput

0.445

High

1316749

DNJB8
DnaJ homolog subfamily B member 8

1

13

High-throughput

0.445

High

1316759

S67A1
Solute carrier family 67 member A1

1

3

High-throughput

0.445

High

1316777

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.445

High

1316778

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.445

High

1316784

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.445

High

1316786

XCT
Cystine/glutamate transporter

1

6

High-throughput

0.445

High

1316791

NPTN
Neuroplastin

1

7

High-throughput

0.445

High

1316757

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

94371

D6RA96
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.407

High

1279052

RIC3
Protein RIC-3

1

1

High-throughput

0.407

High

1316745

SPX3
Sugar phosphate exchanger 3

1

1

High-throughput

0.407

High

286560

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

1316753

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1316769

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

85284

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.251

Low

1316776

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025