HitPredict

Interactor 1: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33742100, 16051665
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1360 Hs			1 2414
+	Hs
		794241 MSH2_HUMAN (393-1360): 0: 824: 21.88		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		855581 MSH6_HUMAN (1-1360): 0: 1486: 100.00		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		855521 MSH6_HUMAN (1-1360): 0: 1486: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		794339 MSH2_HUMAN (393-1360): 0: 824: 21.88		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		594194 MSH3_HUMAN (173-1357): 0: 835: 22.16		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		794289 MSH2_HUMAN (393-1360): 0: 824: 21.88		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		331912 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		1123391 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		BRDT_HUMAN (1036-1159): 2.03e-33: 143: 29.84
+	Hs
		631576 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067123 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		331723 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		331815 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		1017344 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		331812 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82