Protein: ATRX
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)

Gene: ATRX
Organism: Homo sapiens
Interactions: 213
UniProt ID: P46100

Gene Ontology (top 5):
GO:0000212 - meiotic spindle organization
GO:0000228 - nuclear chromosome
GO:0000779 - condensed chromosome, centromeric region
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

855427

H33
Histone H3.3

11

20

Small-scale

0.976

High

855419

H4
Histone H4

5

17

Small-scale

0.915

High

855423

H31
Histone H3.1

5

20

Small-scale

0.909

High

855411

BLM
RecQ-like DNA helicase BLM

2

20

Small-scale

0.806

High

855460

H32
Histone H3.2

2

20

Small-scale

0.792

High

277595

H2AY
Core histone macro-H2A.1

2

20

Small-scale

0.789

High

855453

H2B2E
Histone H2B type 2-E

2

20

Small-scale

0.789

High

853191

CBX5
Chromobox protein homolog 5

2

20

Small-scale

0.768

High

855533

DAXX
Death domain-associated protein 6

22

3

Small-scale

0.767

High

855431

RAD51
DNA repair protein RAD51 homolog 1

11

20

Small-scale

0.759

High

418876

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.754

High

855435

CBX3
Chromobox protein homolog 3

2

20

High-throughput

0.754

High

270327

WDR1
WD repeat-containing protein 1

2

11

High-throughput

0.726

High

855426

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.691

High

413373

P53
Cellular tumor antigen p53

4

14

Small-scale

0.688

High

855433

SSRP1
FACT complex subunit SSRP1

4

20

Small-scale

0.686

High

855547

SP16H
FACT complex subunit SPT16

4

8

Small-scale

0.686

High

855422

CSK21
Casein kinase II subunit alpha

3

18

High-throughput

0.675

High

262037

NBN
Nibrin

4

1

Small-scale

0.672

High

855442

IF4A2
Eukaryotic initiation factor 4A-II

1

20

High-throughput

0.665

High

855451

EZH2
Histone-lysine N-methyltransferase EZH2

3

20

Small-scale

0.660

High

63971

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.656

High

855441

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

20

Small-scale

0.647

High

855515

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

2

4

Small-scale

0.639

High

259588

BRD4
Bromodomain-containing protein 4

3

20

High-throughput

0.633

High

855409

MRE11
Double-strand break repair protein MRE11

3

3

Small-scale

0.633

High

625238

CSK22
Casein kinase II subunit alpha'

2

17

High-throughput

0.628

High

256795

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

855406

ATRX
Transcriptional regulator ATRX

1

18

Small-scale

0.618

High

855407

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

855420

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

855446

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

19

High-throughput

0.618

High

855459

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

855489

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

855509

H2B1L
Histone H2B type 1-L

1

20

Small-scale

0.618

High

855526

DDX18
ATP-dependent RNA helicase DDX18

1

20

High-throughput

0.618

High

855536

DDX20
Probable ATP-dependent RNA helicase DDX20

1

20

High-throughput

0.618

High

855540

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

20

Small-scale

0.614

High

855458

IFIX
Pyrin and HIN domain-containing protein 1

2

10

High-throughput

0.611

High

855525

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

2

4

Small-scale

0.611

High

855417

SUMO2
Small ubiquitin-related modifier 2

2

20

High-throughput

0.602

High

855440

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

2

20

High-throughput

0.601

High

855488

RAD50
DNA repair protein RAD50

2

20

Small-scale

0.594

High

557931

XRCC6
X-ray repair cross-complementing protein 6

2

14

Small-scale

0.584

High

694856

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

15

Small-scale

0.584

High

713934

PML
Protein PML

2

20

Small-scale

0.584

High

855472

SLX4
Structure-specific endonuclease subunit SLX4

2

12

High-throughput

0.584

High

855512

FACD2
Fanconi anemia group D2 protein

2

6

Small-scale

0.584

High

395656

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

354211

ZBED1
E3 SUMO-protein ligase ZBED1

1

4

Small-scale

0.561

High

345491

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.553

High

855498

CFA44
Cilia- and flagella-associated protein 44

1

11

High-throughput

0.553

High

708834

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

4

High-throughput

0.541

High

771862

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.541

High

855415

RBM11
Splicing regulator RBM11

1

11

High-throughput

0.541

High

481145

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

634343

LMNB1
Lamin-B1

1

20

High-throughput

0.536

High

837434

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.536

High

855455

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.536

High

855505

TCPQM
T-complex protein 1 subunit theta-like 2

1

11

High-throughput

0.536

High

855537

ING1
Inhibitor of growth protein 1

1

18

High-throughput

0.536

High

855519

BRD9
Bromodomain-containing protein 9

1

20

Small-scale

0.527

High

855445

SMC1A
Structural maintenance of chromosomes protein 1A

1

17

Small-scale

0.515

High

855496

Z512B
Zinc finger protein 512B

1

20

High-throughput

0.508

High

855503

NEK1
Serine/threonine-protein kinase Nek1

1

11

Small-scale

0.508

High

170002

AURKA
Aurora kinase A

1

7

Small-scale

0.501

High

855497

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.501

High

249103

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.494

High

636716

PTN
Pleiotrophin

1

1

High-throughput

0.494

High

855500

CLIC6
Chloride intracellular channel protein 6

1

4

High-throughput

0.494

High

855545

LC7L2
Putative RNA-binding protein Luc7-like 2

1

6

High-throughput

0.494

High

559903

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.493

High

855543

E41L3
Band 4.1-like protein 3

1

5

High-throughput

0.489

High

855413

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.481

High

855486

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

855491

R51A1
RAD51-associated protein 1

1

0

Small-scale

0.480

High

126071

AP3B1
AP-3 complex subunit beta-1

1

3

High-throughput

0.479

High

128840

MEN1
Menin

1

8

Small-scale

0.479

High

130399

SPT5H
Transcription elongation factor SPT5

1

12

Small-scale

0.479

High

140799

NOP56
Nucleolar protein 56

1

11

Small-scale

0.479

High

142889

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

163722

TCRG1
Transcription elongation regulator 1

1

9

Small-scale

0.479

High

168204

HAT1
Histone acetyltransferase type B catalytic subunit

1

4

High-throughput

0.479

High

222803

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

298321

DNJC8
DnaJ homolog subfamily C member 8

1

7

High-throughput

0.479

High

316777

MTA2
Metastasis-associated protein MTA2

1

20

Small-scale

0.479

High

322491

ABLM3
Actin-binding LIM protein 3

1

2

Small-scale

0.479

High

333962

SMC2
Structural maintenance of chromosomes protein 2

1

17

Small-scale

0.479

High

352086

MBD3
Methyl-CpG-binding domain protein 3

1

20

Small-scale

0.479

High

355449

NSD2
Histone-lysine N-methyltransferase NSD2

1

20

Small-scale

0.479

High

431529

AP2A
Transcription factor AP-2-alpha

1

1

Small-scale

0.479

High

473850

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519826

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

539968

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.479

High

550912

PCNA
Proliferating cell nuclear antigen

1

9

Small-scale

0.479

High

559257

XRCC5
X-ray repair cross-complementing protein 5

1

14

Small-scale

0.479

High

588135

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.479

High

595703

H13
Histone H1.3

1

16

High-throughput

0.479

High

595987

H12
Histone H1.2

1

16

Small-scale

0.479

High

599713

YBOX3
Y-box-binding protein 3

1

4

Small-scale

0.479

High

616266

RCC1
Regulator of chromosome condensation

1

4

High-throughput

0.479

High

637000

VATB2
V-type proton ATPase subunit B, brain isoform

1

8

High-throughput

0.479

High

683795

MOES
Moesin

1

6

High-throughput

0.479

High

702894

DPOD1
DNA polymerase delta catalytic subunit

1

4

High-throughput

0.479

High

718516

CDC27
Cell division cycle protein 27 homolog

1

10

Small-scale

0.479

High

728098

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.479

High

755660

MCM4
DNA replication licensing factor MCM4

1

11

Small-scale

0.479

High

756119

MCM7
DNA replication licensing factor MCM7

1

11

Small-scale

0.479

High

765223

BMI1
Polycomb complex protein BMI-1

1

19

Small-scale

0.479

High

767632

RFA3
Replication protein A 14 kDa subunit

1

10

High-throughput

0.479

High

769939

RFC1
Replication factor C subunit 1

1

11

Small-scale

0.479

High

770350

T2FA
General transcription factor IIF subunit 1

1

3

Small-scale

0.479

High

771569

HXD13
Homeobox protein Hox-D13

1

7

Small-scale

0.479

High

833897

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

855408

MCM2
DNA replication licensing factor MCM2

1

13

Small-scale

0.479

High

855410

MECP2
Methyl-CpG-binding protein 2

1

20

Small-scale

0.479

High

855412

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

855414

PER3
Period circadian protein homolog 3

1

9

High-throughput

0.479

High

855416

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.479

High

855418

RS7
Small ribosomal subunit protein eS7

1

4

High-throughput

0.479

High

855421

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

855424

PHC1
Polyhomeotic-like protein 1

1

9

Small-scale

0.479

High

855425

PRKDC
DNA-dependent protein kinase catalytic subunit

1

12

Small-scale

0.479

High

855430

CENPC
Centromere protein C

1

7

Small-scale

0.479

High

855434

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

855436

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

855437

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.479

High

855438

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

855439

SNW1
SNW domain-containing protein 1

1

10

High-throughput

0.479

High

855443

RBM39
RNA-binding protein 39

1

15

Small-scale

0.479

High

855444

MCM6
DNA replication licensing factor MCM6

1

13

Small-scale

0.479

High

855447

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

855448

SETB1
Histone-lysine N-methyltransferase SETDB1

1

20

Small-scale

0.479

High

855449

EEA1
Early endosome antigen 1

1

18

High-throughput

0.479

High

855452

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

1

High-throughput

0.479

High

855456

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

2

Small-scale

0.479

High

855461

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

15

High-throughput

0.479

High

855463

ZFHX4
Zinc finger homeobox protein 4

1

6

Small-scale

0.479

High

855464

NAA40
N-alpha-acetyltransferase 40

1

7

High-throughput

0.479

High

855467

P66A
Transcriptional repressor p66-alpha

1

14

Small-scale

0.479

High

855468

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

17

Small-scale

0.479

High

855471

SMC5
Structural maintenance of chromosomes protein 5

1

18

High-throughput

0.479

High

855473

ZN687
Zinc finger protein 687

1

8

Small-scale

0.479

High

855475

SIR6
NAD-dependent protein deacylase sirtuin-6

1

12

High-throughput

0.479

High

855476

PAF1
RNA polymerase II-associated factor 1 homolog

1

6

Small-scale

0.479

High

855478

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

855479

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

6

Small-scale

0.479

High

855481

P66B
Transcriptional repressor p66-beta

1

14

Small-scale

0.479

High

855482

THAP4
Peroxynitrite isomerase THAP4

1

3

Small-scale

0.479

High

855483

TOPB1
DNA topoisomerase 2-binding protein 1

1

10

High-throughput

0.479

High

855484

ZN592
Zinc finger protein 592

1

8

Small-scale

0.479

High

855485

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

855487

KAT6A
Histone acetyltransferase KAT6A

1

19

High-throughput

0.479

High

855490

FUBP1
Far upstream element-binding protein 1

1

17

Small-scale

0.479

High

855492

ZN274
Neurotrophin receptor-interacting factor homolog

1

13

Small-scale

0.479

High

855493

TONSL
Tonsoku-like protein

1

9

High-throughput

0.479

High

855501

RBM14
RNA-binding protein 14

1

13

High-throughput

0.479

High

855504

WRIP1
ATPase WRNIP1

1

9

Small-scale

0.479

High

855507

FEV
Protein FEV

1

20

High-throughput

0.479

High

855510

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

8

High-throughput

0.479

High

855511

HIRP3
HIRA-interacting protein 3

1

2

High-throughput

0.479

High

855513

SETD2
Histone-lysine N-methyltransferase SETD2

1

15

Small-scale

0.479

High

855514

SENP6
Sentrin-specific protease 6

1

3

Small-scale

0.479

High

855516

ADNP
Activity-dependent neuroprotector homeobox protein

1

8

Small-scale

0.479

High

855517

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

855523

SALL1
Sal-like protein 1

1

11

Small-scale

0.479

High

855528

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

7

Small-scale

0.479

High

855531

ZMYM2
Zinc finger MYM-type protein 2

1

6

Small-scale

0.479

High

855532

CFDP1
Craniofacial development protein 1

1

2

Small-scale

0.479

High

855534

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

855535

TBK1
Serine/threonine-protein kinase TBK1

1

7

High-throughput

0.479

High

855539

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

Small-scale

0.479

High

855541

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.479

High

855542

SMC3
Structural maintenance of chromosomes protein 3

1

17

Small-scale

0.479

High

855544

ZN281
Zinc finger protein 281

1

4

Small-scale

0.479

High

855546

ARI1
E3 ubiquitin-protein ligase ARIH1

1

9

High-throughput

0.479

High

855548

MORC2
ATPase MORC2

1

3

Small-scale

0.479

High

855529

RRBP1
Ribosome-binding protein 1

1

15

High-throughput

0.470

High

336371

SVIL
Supervillin

1

0

Small-scale

0.460

High

253194

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

855454

SPIN3
Spindlin-3

1

0

High-throughput

0.458

High

855470

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

Small-scale

0.458

High

855480

CATIN
Splicing factor Cactin

1

0

Small-scale

0.458

High

855494

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.458

High

855495

EAF1
ELL-associated factor 1

1

0

High-throughput

0.458

High

855499

ZMAT2
Zinc finger matrin-type protein 2

1

0

Small-scale

0.458

High

855508

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

855520

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

855527

GID8
Glucose-induced degradation protein 8 homolog

1

0

High-throughput

0.458

High

855432

FMR1
Fragile X messenger ribonucleoprotein 1

1

14

High-throughput

0.457

High

855538

TNIK
TRAF2 and NCK-interacting protein kinase

1

7

High-throughput

0.457

High

516477

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

563381

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

133002

MATN2
Matrilin-2

1

9

High-throughput

0.437

High

855429

ANK2
Ankyrin-2

1

3

High-throughput

0.437

High

855462

KTN1
Kinectin

1

14

High-throughput

0.437

High

855465

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.437

High

855474

RAB42
Ras-related protein Rab-42

1

1

High-throughput

0.437

High

855477

MUT7
Exonuclease mut-7 homolog

1

5

High-throughput

0.437

High

855502

KLHL5
Kelch-like protein 5

1

2

High-throughput

0.437

High

855428

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.408

High

855522

RASF1
Ras association domain-containing protein 1

1

1

Small-scale

0.408

High

855506

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.407

High

855524

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.292

High

855518

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.282

High

855530

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

855450

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.269

Low

622495

TNNI3
Troponin I, cardiac muscle

1

0

High-throughput

0.249

Low

855457

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

855466

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.249

Low

855469

CCD71
Coiled-coil domain-containing protein 71

1

0

Small-scale

0.249

Low

855521

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025