HitPredict

Interactor 1: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1360 Hs			1 126
+	Hs
		855491 MSH6_HUMAN (1-1360): 0: 1486: 100.00		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		855449 MSH6_HUMAN (1-1360): 0: 1486: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		855445 MSH6_HUMAN (1-1360): 0: 1486: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		594183 MSH3_HUMAN (173-1357): 0: 835: 22.16		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		594204 MSH3_HUMAN (173-1357): 0: 835: 22.16		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		794229 MSH2_HUMAN (393-1360): 0: 824: 21.88		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		794264 MSH2_HUMAN (393-1360): 0: 824: 21.88		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Sc
		355996 MSH6_YEAST (115-1347): 0: 821: 28.54		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355363 MSH3_YEAST (404-1356): 0: 630: 22.58		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1087385 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918663 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707738 NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		331768 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		331825 NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00