HitPredict

Interactor 1: EFNA4 (P52798)
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Gene: EFNA4

Interactor 2: EPHA6 (Q9UF33)
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)
Gene: EPHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 23686814
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005005 - transmembrane-ephrin receptor activity GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 201 Hs			1 1036
+	Hs
		856385 EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00		EPHA7_HUMAN (9-1036): 0: 1192: 55.53
+	Hs
		856348 EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00		EPHA4_HUMAN (15-1036): 0: 1176: 56.88
+	Hs
		665380 EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Hs
		856508 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHA5_HUMAN (11-1028): 0: 1177: 56.86
+	Hs
		856595 EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37		EPHA5_HUMAN (11-1028): 0: 1177: 56.86
+	Hs
		856510 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHA4_HUMAN (15-1036): 0: 1176: 56.88
+	Mm
		856591 EFNB2_MOUSE (11-183): 3.95e-73: 226: 28.98		EPHA4_MOUSE (15-1036): 0: 1174: 57.07
+	Hs
		665381 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Hs
		665382 EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Mm
		856589 EFNB2_MOUSE (11-183): 3.95e-73: 226: 28.98		EPHB2_MOUSE (34-1034): 0: 1140: 51.29
+	Hs
		665565 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHB2_HUMAN (34-1036): 0: 1138: 51.33
+	Hs
		665458 EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00		EPHA8_HUMAN (34-1036): 0: 1095: 52.45
+	Hs
		665459 EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37		EPHA8_HUMAN (34-1036): 0: 1095: 52.45
+	Hs
		856507 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHB3_HUMAN (31-1029): 0: 1088: 51.53
+	Mm
		856588 EFNB2_MOUSE (11-183): 3.95e-73: 226: 28.98		EPHB3_MOUSE (32-1029): 0: 1085: 51.53
+	Hs
		665180 EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00		EPHA2_HUMAN (6-1036): 0: 1046: 45.57
+	Hs
		665181 EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37		EPHA2_HUMAN (6-1036): 0: 1046: 45.57
+	Hs
		856509 EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84		EPHB4_HUMAN (17-1025): 0: 970: 45.86
+	Mm
		139050 EFNA4_MOUSE (1-182): 3.59e-86: 254: 81.28		EPHA1_MOUSE (30-1023): 0: 934: 40.36
+	Hs
		522869 EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37		SRC_HUMAN (623-931): 3.42e-59: 214: 40.32