HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27173435, 15654075, 31730000
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 821
+	Xl
		936129 PLK1_XENLA (21-603): 0: 590: 80.38		MC6ZA_XENLA (1-821): 0: 829: 81.68
+	Hs
		708584 PLK1_HUMAN (1-603): 0: 617: 100.00		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		627218 PLK1_HUMAN (1-603): 0: 617: 100.00		MCM3_HUMAN (18-813): 0: 639: 25.76
+	Hs
		708848 PLK1_HUMAN (1-603): 0: 617: 100.00		MCM7_HUMAN (22-713): 0: 634: 28.88
+	Hs
		708406 PLK1_HUMAN (1-603): 0: 617: 100.00		MCM4_HUMAN (2-736): 0: 632: 27.70
+	Hs
		832257 PLK1_HUMAN (1-603): 0: 617: 100.00		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Xl
		879168 PLK1_XENLA (21-603): 0: 590: 80.38		MCM2_XENLA (21-732): 0: 637: 27.52
+	Xl
		936130 PLK1_XENLA (21-603): 0: 590: 80.38		MCM4A_XENLA (15-730): 0: 626: 27.05
+	Hs
		627383 KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66		MCM3_HUMAN (18-813): 0: 639: 25.76
+	Xl
		936138 PLK1_XENLA (21-603): 0: 590: 80.38		MCM7A_XENLA (123-655): 7.97e-86: 290: 34.94