HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 27173435
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 864
+	Hs
		787876 PLK1_HUMAN (1-603): 0: 617: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		861770 PLK1_HUMAN (1-603): 0: 617: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		160824 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		160427 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		129013 PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70		MRCKA_HUMAN (415-784): 2.54e-20: 99.4: 7.87