Protein: PRP40
Pre-mRNA-processing protein PRP40

Gene: PRP40
Organism: Saccharomyces cerevisiae S288C
Interactions: 164
UniProt ID: P33203

Gene Ontology (top 5):
GO:0000243 - commitment complex
GO:0000395 - mRNA 5'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750218

PRP40
Pre-mRNA-processing protein PRP40

2

5

Small-scale

0.776

High

750314

LUC7
Protein LUC7

7

5

Small-scale

0.751

High

750289

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

7

8

Small-scale

0.745

High

750288

NAM8
Protein NAM8

6

3

Small-scale

0.730

High

750280

SNU71
U1 small nuclear ribonucleoprotein component SNU71

11

0

Small-scale

0.727

High

743512

RU1A
U1 small nuclear ribonucleoprotein A

9

0

Small-scale

0.722

High

750296

PRP42
U1 small nuclear ribonucleoprotein component PRP42

5

2

High-throughput

0.712

High

750249

PRP39
Pre-mRNA-processing factor 39

4

2

High-throughput

0.694

High

750223

NCBP1
Nuclear cap-binding protein complex subunit 1

4

1

High-throughput

0.691

High

750253

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

4

High-throughput

0.691

High

750321

BBP
Branchpoint-bridging protein

4

5

Small-scale

0.690

High

750254

RUXG
Small nuclear ribonucleoprotein G

4

2

High-throughput

0.683

High

750286

RUXF
Small nuclear ribonucleoprotein F

4

4

High-throughput

0.683

High

750297

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

5

0

High-throughput

0.682

High

750316

NCBP2
Nuclear cap-binding protein subunit 2

4

4

Small-scale

0.676

High

750304

RU1C
U1 small nuclear ribonucleoprotein C

4

0

High-throughput

0.664

High

750266

SMD3
Small nuclear ribonucleoprotein Sm D3

3

6

High-throughput

0.662

High

750292

SMD1
Small nuclear ribonucleoprotein Sm D1

4

0

High-throughput

0.661

High

401947

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

Small-scale

0.619

High

750227

MUD2
Splicing factor MUD2

3

0

Small-scale

0.613

High

750326

RUXE
Small nuclear ribonucleoprotein E

2

2

High-throughput

0.601

High

750219

PRP8
Pre-mRNA-splicing factor 8

2

1

Small-scale

0.594

High

526280

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.585

High

750293

CUS1
Cold sensitive U2 snRNA suppressor 1

2

3

High-throughput

0.584

High

750317

RU2A
U2 small nuclear ribonucleoprotein A'

2

4

Small-scale

0.584

High

750307

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

High-throughput

0.576

High

594283

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

694513

SPT5
Transcription elongation factor SPT5

2

0

Small-scale

0.559

High

403427

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.536

High

523479

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.536

High

750324

CLF1
Pre-mRNA-splicing factor CLF1

1

1

Small-scale

0.527

High

416215

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.501

High

628198

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

7

High-throughput

0.501

High

750220

LHP1
La protein homolog

1

3

High-throughput

0.501

High

750236

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.501

High

750238

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

1

High-throughput

0.501

High

750255

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

4

High-throughput

0.501

High

750265

ELP2
Elongator complex protein 2

1

4

High-throughput

0.501

High

750269

AIP1
Actin-interacting protein 1

1

4

High-throughput

0.501

High

750270

YJ66
Uncharacterized oxidoreductase YJR096W

1

1

High-throughput

0.501

High

750274

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

1

High-throughput

0.501

High

750275

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.501

High

750279

STR3
Cystathionine beta-lyase

1

1

High-throughput

0.501

High

750284

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.501

High

750290

CTF4
DNA polymerase alpha-binding protein

1

4

High-throughput

0.501

High

750291

NOP3
Serine/arginine

1

6

High-throughput

0.501

High

750320

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.501

High

750245

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.493

High

733528

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.486

High

750222

NUF2
Kinetochore protein NUF2

1

1

High-throughput

0.481

High

370438

IPA3
Protease A inhibitor 3

1

0

High-throughput

0.480

High

421271

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.480

High

521090

YEY2
Uncharacterized protein YER152C

1

0

High-throughput

0.480

High

584440

IDI1
Isopentenyl-diphosphate delta-isomerase

1

0

High-throughput

0.480

High

632331

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.480

High

677127

POF1
Nicotinamide mononucleotide adenylyltransferase

1

0

High-throughput

0.480

High

677909

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.480

High

750224

SIP2
SNF1 protein kinase subunit beta-2

1

0

High-throughput

0.480

High

750242

DOG2
2-deoxyglucose-6-phosphate phosphatase 2

1

0

High-throughput

0.480

High

750248

STM1
Suppressor protein STM1

1

0

High-throughput

0.480

High

750250

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.480

High

750261

MVP1
Sorting nexin MVP1

1

0

High-throughput

0.480

High

750282

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.480

High

750295

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.480

High

750298

RUB1
NEDD8-like protein RUB1

1

0

High-throughput

0.480

High

750305

KYNU
Kynureninase

1

0

High-throughput

0.480

High

750311

ARR2
Arsenical-resistance protein 2

1

0

High-throughput

0.480

High

750319

LKHA4
Leucine aminopeptidase 2

1

0

High-throughput

0.480

High

638004

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

6

High-throughput

0.479

High

740845

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.479

High

750301

RSE1
Pre-mRNA-splicing factor RSE1

1

6

High-throughput

0.479

High

750312

PRP11
Pre-mRNA-splicing factor PRP11

1

3

High-throughput

0.479

High

750327

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

2

Small-scale

0.479

High

750252

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

706636

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

747776

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

750228

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

750237

STS1
Tethering factor for nuclear proteasome STS1

1

0

High-throughput

0.458

High

553968

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.457

High

598986

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.457

High

668332

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.457

High

668425

PTP1
Tyrosine-protein phosphatase 1

1

7

High-throughput

0.457

High

672488

SYNM
Asparagine--tRNA ligase, mitochondrial

1

1

High-throughput

0.457

High

676872

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

736075

ARP2
Actin-related protein 2

1

7

High-throughput

0.457

High

736478

MDHP
Malate dehydrogenase, peroxisomal

1

1

High-throughput

0.457

High

743813

FRDS
Fumarate reductase 1

1

1

High-throughput

0.457

High

750229

TGL4
Triacylglycerol lipase 4

1

1

High-throughput

0.457

High

750234

MAL32
Alpha-glucosidase MAL32

1

1

High-throughput

0.457

High

750239

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.457

High

750260

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

1

High-throughput

0.457

High

750273

YPT11
GTP-binding protein YPT11

1

1

High-throughput

0.457

High

750278

MALX3
Oligo-1,6-glucosidase IMA1

1

1

High-throughput

0.457

High

750323

YD061
Uncharacterized ABC transporter ATP-binding protein YDR061W

1

2

High-throughput

0.457

High

750325

PRR2
Serine/threonine-protein kinase PRR2

1

3

High-throughput

0.457

High

392479

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

481563

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

544306

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

739121

PRP19
Pre-mRNA-processing factor 19

1

1

Small-scale

0.445

High

741261

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

750308

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.438

High

750232

YPK3
Serine/threonine-protein kinase YPK3

1

1

High-throughput

0.437

High

670523

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

579111

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.407

High

750251

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.407

High

750256

TGL3
Triacylglycerol lipase 3

1

1

High-throughput

0.373

High

750257

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.279

Low

750277

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.279

Low

150215

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.261

Low

367935

ENO2
Enolase 2

1

0

High-throughput

0.261

Low

368885

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.261

Low

416100

SYTC
Threonine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.261

Low

441809

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.261

Low

446220

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.261

Low

449101

CALM
Calmodulin

1

0

High-throughput

0.261

Low

534177

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.261

Low

538334

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.261

Low

541277

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.261

Low

582235

AMPD
AMP deaminase

1

0

High-throughput

0.261

Low

655563

TKT1
Transketolase 1

1

0

High-throughput

0.261

Low

660218

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.261

Low

723595

MLS1
Malate synthase 1

1

0

High-throughput

0.261

Low

737155

ERG24
Delta(14)-sterol reductase ERG24

1

0

High-throughput

0.261

Low

745317

EMP24
Endosomal protein P24B

1

0

High-throughput

0.261

Low

750225

THI80
Thiamine pyrophosphokinase

1

0

High-throughput

0.261

Low

750226

MCR1
NADH-cytochrome b5 reductase 2

1

0

High-throughput

0.261

Low

750231

ADCS
Aminodeoxychorismate synthase

1

0

High-throughput

0.261

Low

750233

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.261

Low

750235

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.261

Low

750240

YHE2
Putative uncharacterized protein YHL042W

1

0

High-throughput

0.261

Low

750241

TDA3
Putative oxidoreductase TDA3

1

0

High-throughput

0.261

Low

750243

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.261

Low

750244

HTD2
Hydroxyacyl-thioester dehydratase type 2, mitochondrial

1

0

High-throughput

0.261

Low

750246

YH02
Uncharacterized protein YHR202W

1

0

High-throughput

0.261

Low

750247

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.261

Low

750258

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.261

Low

750262

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.261

Low

750263

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.261

Low

750267

MTHR1
Methylenetetrahydrofolate reductase 1

1

0

High-throughput

0.261

Low

750268

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.261

Low

750271

PXP2
Peroxisomal protein 2

1

0

High-throughput

0.261

Low

750272

2NDP
Putative nitronate monooxygenase

1

0

High-throughput

0.261

Low

750283

YNW6
Putative uncharacterized protein YNL226W

1

0

High-throughput

0.261

Low

750285

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.261

Low

750287

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.261

Low

750294

NGL3
Probable RNA exonuclease NGL3

1

0

High-throughput

0.261

Low

750299

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.261

Low

750300

HFD1
Fatty aldehyde dehydrogenase HFD1

1

0

High-throughput

0.261

Low

750302

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.261

Low

750303

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.261

Low

750306

PEX30
Peroxisomal membrane protein PEX30

1

0

High-throughput

0.261

Low

750309

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.261

Low

750310

YP147
Lipid droplet-associated triacylglycerol lipase

1

0

High-throughput

0.261

Low

750313

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

750315

FOLE
Folylpolyglutamate synthase

1

0

High-throughput

0.261

Low

750318

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.261

Low

750322

COX17
Cytochrome c oxidase copper chaperone

1

0

High-throughput

0.261

Low

750230

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

750276

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

750281

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

750221

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

750264

MDJ2
Mitochondrial DnaJ homolog 2

1

0

High-throughput

0.232

Low

750259

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.213

Low


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Last updated: 11Aug2025