HitPredict

Interactor 1: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21134130
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0017148 - negative regulation of translation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1430 Hs			1 1164
+	Mm
		515253 KCC2A_MOUSE (1-383): 5.07e-120: 385: 29.17		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Mm
		1161541 KCC2D_MOUSE (2-383): 1.06e-116: 377: 27.94		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		1051522 KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		149396 DAPK2_HUMAN (1-351): 4.95e-141: 437: 68.27		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		200129 DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		200091 DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		724782 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148160 DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		1253143 KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17		PMFBP_HUMAN (586-1055): 9.54e-14: 78: 14.54
+	Hs
		725139 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		1189816 ANR50_HUMAN (250-749): 3.44e-97: 345: 21.39		MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11
+	Hs
		724846 MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Mm
		57834 KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91		CTRO_MOUSE (337-1025): 1.01e-24: 114: 9.83
+	Hs
		166927 ANR28_HUMAN (257-531): 1.54e-27: 123: 19.64		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Rn
		222475 KALRN_RAT (2-312): 1.07e-61: 236: 38.91		MRCKA_RAT (415-804): 5.64e-14: 79.1: 8.05
+	Rn
		957077 KALRN_RAT (2-312): 1.07e-61: 236: 38.91		MRCKB_RAT (856-1164): 4.53e-12: 72.9: 10.10