HitPredict

Interactor 1: RCAN1 (P53805)
Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)
Gene: RCAN1

Interactor 2: PP2BA (Q08209)
Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
Gene: PPP3CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	26186194, 27880917, 23118980, 28514442, 10861295, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0033173 - calcineurin-NFAT signaling cascade GO:0048741 - skeletal muscle fiber development
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 252 Hs			1 521
+	Hs
		557530 RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00		PP2BB_HUMAN (15-515): 0: 815: 84.63
+	Hs
		819141 RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00		PP2BC_HUMAN (11-518): 0: 807: 80.51
+	Hs
		994080 RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20		PP2BA_HUMAN (1-521): 0: 896: 100.00
+	Hs
		994121 RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00		PP2BA_HUMAN (1-521): 0: 896: 100.00
+	Hs
		557546 RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20		PP2BB_HUMAN (15-515): 0: 815: 84.63
+	Hs
		557578 RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00		PP2BB_HUMAN (15-515): 0: 815: 84.63
+	Hs
		819151 RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20		PP2BC_HUMAN (11-518): 0: 807: 80.51
+	Hs
		819181 RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00		PP2BC_HUMAN (11-518): 0: 807: 80.51
+	Ce
		865127 RCANL_CAEEL (62-234): 1.65e-87: 260: 42.61		PP2B_CAEEL (14-517): 0: 751: 73.18
+	Dm
		1099957 SRA_DROME (55-245): 1.33e-71: 222: 39.38		PP2B2_DROME (11-495): 0: 764: 80.33
+	Dm
		1375383 SRA_DROME (55-245): 1.33e-71: 222: 39.38		PP2B3_DROME (11-495): 0: 761: 80.74