Protein: B2CL1
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)

Gene: B2CL1, BCL2L1
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q07817

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0001701 - in utero embryonic development
GO:0001836 - release of cytochrome c from mitochondria
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992105

BAD
Bcl2-associated agonist of cell death

39

8

Small-scale

0.995

High

991994

BAX
Apoptosis regulator BAX

32

18

Small-scale

0.993

High

992082

BAK
Bcl-2 homologous antagonist/killer

22

17

Small-scale

0.991

High

206739

B2L11
Bcl-2-like protein 11

22

17

Small-scale

0.990

High

992077

BECN1
Beclin-1

16

8

Small-scale

0.987

High

386599

P53
Cellular tumor antigen p53

11

9

Small-scale

0.984

High

879514

BID
BH3-interacting domain death agonist

9

10

Small-scale

0.971

High

992114

BMF
Bcl-2-modifying factor

7

8

Small-scale

0.963

High

489402

BCL2
Apoptosis regulator Bcl-2

6

17

Small-scale

0.946

High

992123

BBC3
Bcl-2-binding component 3, isoforms 1/2

5

7

Small-scale

0.931

High

992074

APR
Phorbol-12-myristate-13-acetate-induced protein 1

4

7

Small-scale

0.885

High

992065

B2CL1
Bcl-2-like protein 1

3

17

Small-scale

0.861

High

992073

ASPP2
Apoptosis-stimulating of p53 protein 2

2

4

Small-scale

0.826

High

992126

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

2

Small-scale

0.812

High

992072

BIK
Bcl-2-interacting killer

12

6

Small-scale

0.760

High

152872

APAF
Apoptotic protease-activating factor 1

2

1

Small-scale

0.754

High

119881

HRK
Activator of apoptosis harakiri

7

4

Small-scale

0.746

High

992116

BBC3B
Bcl-2-binding component 3, isoforms 3/4

7

5

Small-scale

0.736

High

601227

VDAC1
Voltage-dependent anion-selective channel protein 1

5

8

Small-scale

0.726

High

227261

PRKN
E3 ubiquitin-protein ligase parkin

3

7

Small-scale

0.678

High

940818

RNF4
E3 ubiquitin-protein ligase RNF4

3

2

High-throughput

0.653

High

787462

MTOR
Serine/threonine-protein kinase mTOR

2

1

Small-scale

0.653

High

175432

SIVA
Apoptosis regulatory protein Siva

2

2

Small-scale

0.646

High

992084

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

3

0

High-throughput

0.638

High

847449

BAP31
B-cell receptor-associated protein 31

2

1

Small-scale

0.634

High

905852

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

11

Small-scale

0.634

High

992124

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

6

Small-scale

0.624

High

992119

RAD9A
Cell cycle checkpoint control protein RAD9A

2

2

Small-scale

0.620

High

667451

CASP1
Caspase-1

1

8

Small-scale

0.618

High

876975

CASP9
Caspase-9

1

8

Small-scale

0.618

High

992066

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

16

Small-scale

0.618

High

992138

B2L10
Bcl-2-like protein 10

1

4

Small-scale

0.618

High

928271

DYL1
Dynein light chain 1, cytoplasmic

2

4

Small-scale

0.611

High

648279

G0S2
G0/G1 switch protein 2

2

1

High-throughput

0.606

High

992088

GORAB
RAB6-interacting golgin

2

1

High-throughput

0.606

High

992100

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

1

High-throughput

0.606

High

992153

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.606

High

500779

CLUS
Clusterin

2

1

Small-scale

0.606

High

800759

MK08
Mitogen-activated protein kinase 8

2

13

Small-scale

0.602

High

992076

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

2

Small-scale

0.595

High

414887

CDK1
Cyclin-dependent kinase 1

2

5

Small-scale

0.584

High

870769

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

2

Small-scale

0.584

High

992152

UBP18
Ubl carboxyl-terminal hydrolase 18

2

2

Small-scale

0.584

High

881471

TM50B
Transmembrane protein 50B

2

0

High-throughput

0.580

High

992128

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.580

High

992131

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.580

High

992134

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.580

High

992108

RN183
E3 ubiquitin-protein ligase RNF183

1

1

Small-scale

0.578

High

834962

PSN2
Presenilin-2

1

4

Small-scale

0.573

High

216713

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

358750

CRYAA
Alpha-crystallin A chain

1

6

Small-scale

0.561

High

359005

CRYAB
Alpha-crystallin B chain

1

6

Small-scale

0.561

High

532513

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.561

High

790758

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.561

High

992101

BLID
BH3-like motif-containing cell death inducer

1

1

Small-scale

0.561

High

992118

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.561

High

473057

BNIP5
Protein BNIP5

2

2

High-throughput

0.553

High

992089

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.553

High

992070

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

5

Small-scale

0.552

High

992083

RTN1
Reticulon-1

1

3

Small-scale

0.552

High

992140

RTN4
Reticulon-4

1

4

Small-scale

0.552

High

992142

AVEN
Cell death regulator Aven

1

1

Small-scale

0.552

High

992149

IKZF3
Zinc finger protein Aiolos

1

1

Small-scale

0.552

High

64238

ZAR1L
Protein ZAR1-like

1

1

High-throughput

0.536

High

475006

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.536

High

992087

MBRL
Membralin

1

1

High-throughput

0.536

High

992110

DYL2
Dynein light chain 2, cytoplasmic

1

4

High-throughput

0.536

High

992144

WSB2
WD repeat and SOCS box-containing protein 2

1

1

High-throughput

0.536

High

992154

KLH20
Kelch-like protein 20

1

1

High-throughput

0.536

High

992155

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.536

High

992080

RYR3
Ryanodine receptor 3

1

5

Small-scale

0.523

High

337445

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.515

High

737765

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

11

High-throughput

0.515

High

992132

SPNS1
Protein spinster homolog 1

1

1

Small-scale

0.515

High

742248

SYUA
Alpha-synuclein

1

1

High-throughput

0.515

High

992086

ANO6
Anoctamin-6

1

0

High-throughput

0.513

High

992121

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.513

High

992117

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.512

High

834272

PSN1
Presenilin-1

1

4

Small-scale

0.508

High

891718

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.508

High

992136

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

2

High-throughput

0.508

High

160531

AURKA
Aurora kinase A

1

4

Small-scale

0.501

High

225185

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

5

Small-scale

0.501

High

374107

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

Small-scale

0.501

High

681808

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.501

High

800873

MK09
Mitogen-activated protein kinase 9

1

13

Small-scale

0.501

High

835343

GSK3A
Glycogen synthase kinase-3 alpha

1

9

Small-scale

0.501

High

835694

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.501

High

846462

BLK
Tyrosine-protein kinase Blk

1

3

Small-scale

0.501

High

861713

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.501

High

992069

SEC20
Vesicle transport protein SEC20

1

1

Small-scale

0.501

High

992081

MK14
Mitogen-activated protein kinase 14

1

14

Small-scale

0.501

High

992133

PLK3
Serine/threonine-protein kinase PLK3

1

2

Small-scale

0.501

High

992097

VRK2
Serine/threonine-protein kinase VRK2

1

2

Small-scale

0.500

High

992130

ATG5
Autophagy protein 5

1

0

Small-scale

0.493

High

992095

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

1

High-throughput

0.489

High

450853

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.486

High

531808

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.486

High

597383

PTN
Pleiotrophin

1

0

High-throughput

0.486

High

825684

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.486

High

980589

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.486

High

992090

LARP1
La-related protein 1

1

0

High-throughput

0.486

High

992096

MET23
Histone-arginine methyltransferase METTL23

1

0

High-throughput

0.486

High

992099

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.486

High

992104

PPHLN
Periphilin-1

1

0

High-throughput

0.486

High

992137

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.486

High

992150

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.486

High

992092

BOP
Protein Bop

1

6

Small-scale

0.484

High

930167

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

992067

VAC14
Protein VAC14 homolog

1

2

High-throughput

0.481

High

992093

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

3

Small-scale

0.481

High

154173

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

824629

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.480

High

117675

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.479

High

128150

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

128540

DNM1L
Dynamin-1-like protein

1

3

Small-scale

0.479

High

150559

ABLM1
Actin-binding LIM protein 1

1

3

High-throughput

0.479

High

181603

CFLAR
CASP8 and FADD-like apoptosis regulator

1

8

Small-scale

0.479

High

350108

RASK
GTPase KRas

1

6

High-throughput

0.479

High

381947

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

388400

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.479

High

499706

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.479

High

542293

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

646830

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

717028

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

724538

IRS1
Insulin receptor substrate 1

1

3

Small-scale

0.479

High

799977

VDAC2
Voltage-dependent anion-selective channel protein 2

1

8

High-throughput

0.479

High

834723

RBP2
E3 SUMO-protein ligase RanBP2

1

3

High-throughput

0.479

High

868157

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

880695

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

896877

ARP2
Actin-related protein 2

1

3

High-throughput

0.479

High

926575

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

1

High-throughput

0.479

High

926675

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

High-throughput

0.479

High

933413

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.479

High

944200

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

962030

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

963301

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

High-throughput

0.479

High

981949

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

992068

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

992071

TRI32
E3 ubiquitin-protein ligase TRIM32

1

5

Small-scale

0.479

High

992075

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.479

High

992078

CASP8
Caspase-8

1

8

Small-scale

0.479

High

992079

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.479

High

992106

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

992109

GIMA5
GTPase IMAP family member 5

1

5

Small-scale

0.479

High

992122

LFG2
Protein lifeguard 2

1

4

Small-scale

0.479

High

992127

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

Small-scale

0.479

High

992129

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.479

High

992145

BFAR
Bifunctional apoptosis regulator

1

4

Small-scale

0.479

High

992147

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

992091

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

856056

RBM5
RNA-binding protein 5

1

1

High-throughput

0.464

High

992085

EDRF1
Erythroid differentiation-related factor 1

1

1

High-throughput

0.464

High

992135

B2L12
Bcl-2-like protein 12

1

2

Small-scale

0.464

High

121742

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.458

High

127003

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

159971

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

High-throughput

0.458

High

197285

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

313813

SVIL
Supervillin

1

0

High-throughput

0.458

High

428158

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

448326

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

616271

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

653235

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

671214

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

725145

MYH10
Myosin-10

1

0

High-throughput

0.458

High

813405

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

907650

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

918853

RAB1A
Ras-related protein Rab-1A

1

0

High-throughput

0.458

High

920626

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

923335

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

932667

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

958439

CYC
Cytochrome c

1

0

Small-scale

0.458

High

964910

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

992107

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.458

High

992112

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.458

High

992120

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

992125

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

Small-scale

0.458

High

992141

MID51
Mitochondrial dynamics protein MIEF1

1

0

Small-scale

0.458

High

992148

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.458

High

992151

MYO5B
Unconventional myosin-Vb

1

0

High-throughput

0.458

High

182143

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

3

Small-scale

0.445

High

279530

FLOT1
Flotillin-1

1

1

High-throughput

0.437

High

489017

H14
Histone H1.4

1

1

High-throughput

0.437

High

992102

RN152
E3 ubiquitin-protein ligase RNF152

1

6

Small-scale

0.437

High

992139

DLRB1
Dynein light chain roadblock-type 1

1

0

Small-scale

0.426

High

611568

GNLY
Granulysin

2

0

High-throughput

0.316

High

992094

RIC3
Protein RIC-3

2

0

High-throughput

0.316

High

992103

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

992111

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

992113

TM101
Transmembrane protein 101

1

0

High-throughput

0.279

Low

992098

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.265

Low

992115

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.265

Low

992146

ZN219
Zinc finger protein 219

1

0

High-throughput

0.265

Low

992143

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024