HitPredict

Interactor 1: RHO1 (P48148)
Ras-like GTP-binding protein Rho1
Gene: RHO1

Interactor 2: AURKB (Q9VKN7)
Aurora kinase B (EC 2.7.11.1) (IPL1/Aurora-like protein kinase) (Serine/threonine-protein kinase Ial) (Serine/threonine-protein kinase aurora-B)
Gene: aurB

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	38944040
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000281 - mitotic cytokinesis GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 329
+	Hs
		988474 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		MARK2_HUMAN (1-320): 4.97e-132: 396: 28.57
+	Hs
		728154 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		AKT1_HUMAN (15-328): 1.31e-134: 392: 28.26
+	Hs
		1015546 RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21		MARK2_HUMAN (1-320): 4.97e-132: 396: 28.57
+	Hs
		962195 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		MARK2_HUMAN (1-320): 4.97e-132: 396: 28.57
+	Hs
		581132 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		MARK2_HUMAN (1-320): 4.97e-132: 396: 28.57
+	Hs
		605631 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		KAPCA_HUMAN (31-327): 5.97e-134: 386: 29.47
+	Hs
		955318 CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89		MARK2_HUMAN (1-320): 4.97e-132: 396: 28.57
+	Hs
		605623 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		KAPCA_HUMAN (31-327): 5.97e-134: 386: 29.47
+	Hs
		580876 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		KAPCB_HUMAN (31-327): 7.51e-134: 386: 30.46
+	Hs
		692037 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		466097 RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94		KAPCA_HUMAN (31-327): 5.97e-134: 386: 29.47
+	Hs
		605617 CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89		KAPCA_HUMAN (31-327): 5.97e-134: 386: 29.47
+	Hs
		692027 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		692041 RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		169924 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		AURKA_HUMAN (1-325): 1.14e-130: 380: 43.47
+	Hs
		169904 RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94		AURKA_HUMAN (1-325): 1.14e-130: 380: 43.47
+	Hs
		580880 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		466114 RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		692024 CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89		MARK3_HUMAN (10-315): 1.57e-125: 378: 31.39
+	Hs
		962375 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		AURKB_HUMAN (52-307): 2e-90: 275: 52.34