HitPredict

Interactor 1: S12A2 (P55011)
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2)
Gene: SLC12A2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019901 - protein kinase binding GO:0043005 - neuron projection GO:0043025 - neuronal cell body and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1212 Hs			1 191
+	Hs
		564463 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		873980 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		873903 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		873907 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		873898 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545288 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436225 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		873895 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		873941 S12A2_HUMAN (1-1212): 0: 1285: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		564740 S12A4_HUMAN (167-1212): 0: 914: 23.71		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		925735 S12A4_HUMAN (167-1212): 0: 914: 23.71		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		951440 S12A6_HUMAN (148-1212): 0: 918: 22.65		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		894592 S12A4_HUMAN (167-1212): 0: 914: 23.71		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951460 S12A4_HUMAN (167-1212): 0: 914: 23.71		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		901055 S12A4_HUMAN (167-1212): 0: 914: 23.71		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545701 S12A4_HUMAN (167-1212): 0: 914: 23.71		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436575 S12A4_HUMAN (167-1212): 0: 914: 23.71		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892682 S12A4_HUMAN (167-1212): 0: 914: 23.71		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		1183597 S12A6_HUMAN (148-1212): 0: 918: 22.65		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		1183612 S12A4_HUMAN (167-1212): 0: 914: 23.71		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82