Protein: NLRP3
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)

Gene: NLRP3
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q96P20

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002674 - negative regulation of acute inflammatory response
GO:0002830 - positive regulation of type 2 immune response
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1299043

ASC
Apoptosis-associated speck-like protein containing a CARD

23

18

Small-scale

0.987

High

1255579

NEK7
Serine/threonine-protein kinase Nek7

9

3

Small-scale

0.969

High

1299023

NLRP3
NACHT, LRR and PYD domains-containing protein 3

4

17

Small-scale

0.871

High

1299042

FBXL2
F-box/LRR-repeat protein 2

2

9

Small-scale

0.825

High

183332

MEFV
Pyrin

2

13

Small-scale

0.754

High

262305

ULK1
Serine/threonine-protein kinase ULK1

2

2

Small-scale

0.754

High

585532

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

7

Small-scale

0.724

High

822131

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.724

High

1299026

TXNIP
Thioredoxin-interacting protein

5

1

Small-scale

0.702

High

886444

NALP5
NACHT, LRR and PYD domains-containing protein 5

1

16

High-throughput

0.691

High

1296782

MARK4
MAP/microtubule affinity-regulating kinase 4

1

0

Small-scale

0.687

High

1190065

MAVS
Mitochondrial antiviral-signaling protein

4

2

Small-scale

0.683

High

667484

CASP1
Caspase-1

4

20

Small-scale

0.676

High

805553

BRCC3
Lys-63-specific deubiquitinase BRCC36

4

4

Small-scale

0.676

High

1299025

TRI31
E3 ubiquitin-protein ligase TRIM31

3

13

Small-scale

0.670

High

1299032

NLRC4
NLR family CARD domain-containing protein 4

1

18

Small-scale

0.665

High

1299030

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

18

Small-scale

0.653

High

228404

PRKN
E3 ubiquitin-protein ligase parkin

3

12

Small-scale

0.646

High

214349

SPOP
Speckle-type POZ protein

1

1

Small-scale

0.618

High

432167

HS90A
Heat shock protein HSP 90-alpha

2

7

Small-scale

0.601

High

317753

STABP
STAM-binding protein

2

1

Small-scale

0.595

High

1299046

FAF1
FAS-associated factor 1

1

6

Small-scale

0.586

High

1036822

SQSTM
Sequestosome-1

2

5

Small-scale

0.584

High

1299028

DHX33
ATP-dependent RNA helicase DHX33

2

2

Small-scale

0.584

High

1044064

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.575

High

823475

PAXI
Paxillin

1

1

Small-scale

0.573

High

1041151

CUL1
Cullin-1

1

12

Small-scale

0.568

High

49664

IRGM
Immunity-related GTPase family M protein

1

2

Small-scale

0.561

High

509977

VDR
Vitamin D3 receptor

1

4

Small-scale

0.561

High

796631

KSYK
Tyrosine-protein kinase SYK

1

10

Small-scale

0.561

High

1204904

TRI50
E3 ubiquitin-protein ligase TRIM50

1

13

Small-scale

0.561

High

1238110

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

5

Small-scale

0.553

High

120021

AP3B1
AP-3 complex subunit beta-1

1

1

High-throughput

0.536

High

229464

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

3

High-throughput

0.536

High

243561

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.536

High

299077

PHF14
PHD finger protein 14

1

2

High-throughput

0.536

High

308245

LC7L3
Luc7-like protein 3

1

1

High-throughput

0.536

High

432868

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.536

High

563180

YBOX3
Y-box-binding protein 3

1

2

High-throughput

0.536

High

800499

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.536

High

1027202

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.536

High

1197580

PCGF5
Polycomb group RING finger protein 5

1

7

High-throughput

0.536

High

1231798

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

1

High-throughput

0.536

High

1234111

FBXL6
F-box/LRR-repeat protein 6

1

13

High-throughput

0.536

High

1299024

FEM1A
Protein fem-1 homolog A

1

3

High-throughput

0.536

High

1299036

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.536

High

1299039

SPAST
Spastin

1

5

High-throughput

0.536

High

1299040

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.536

High

1299049

SGT1
Protein SGT1 homolog

1

13

Small-scale

0.529

High

1299044

APC10
Anaphase-promoting complex subunit 10

1

0

Small-scale

0.529

High

739242

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.515

High

157765

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.513

High

159502

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

508666

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

539112

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

559222

H15
Histone H1.5

1

0

High-throughput

0.513

High

1083352

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.513

High

1223560

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.513

High

1235061

ZC3H8
Zinc finger CCCH domain-containing protein 8

1

0

High-throughput

0.513

High

1299027

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.513

High

1299031

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

653098

CD82
CD82 antigen

1

1

Small-scale

0.512

High

1152045

LTOR1
Ragulator complex protein LAMTOR1

1

1

Small-scale

0.504

High

500032

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

653700

CALR
Calreticulin

1

0

High-throughput

0.493

High

1299033

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.489

High

1299034

NECT3
Nectin-3

1

1

High-throughput

0.489

High

124928

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

Small-scale

0.479

High

170452

TIF1A
Transcription intermediary factor 1-alpha

1

10

Small-scale

0.479

High

304299

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

312647

ARI2
E3 ubiquitin-protein ligase ARIH2

1

6

Small-scale

0.479

High

353013

IL1B
Interleukin-1 beta

1

2

Small-scale

0.479

High

523115

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

800619

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

4

Small-scale

0.479

High

870873

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

Small-scale

0.479

High

921397

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

1027622

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.479

High

1029763

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1042319

CUL3
Cullin-3

1

12

Small-scale

0.479

High

1043169

CUL4A
Cullin-4A

1

12

High-throughput

0.479

High

1043523

CUL4B
Cullin-4B

1

12

High-throughput

0.479

High

1054189

BECN1
Beclin-1

1

6

Small-scale

0.479

High

1146749

A16L1
Autophagy-related protein 16-1

1

4

Small-scale

0.479

High

1160570

TRI40
E3 ubiquitin ligase TRIM40

1

12

Small-scale

0.479

High

1162050

TRI65
E3 ubiquitin-protein ligase TRIM65

1

19

Small-scale

0.479

High

1173914

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

2

Small-scale

0.479

High

1254710

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

Small-scale

0.479

High

1273571

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

Small-scale

0.479

High

1273707

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

Small-scale

0.479

High

1290197

RN125
E3 ubiquitin-protein ligase RNF125

1

16

Small-scale

0.479

High

1299029

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

1

Small-scale

0.479

High

1299037

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.479

High

1299038

HDAC6
Histone deacetylase 6

1

4

Small-scale

0.479

High

1299041

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.479

High

1299045

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.479

High

1299047

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1299048

CARD8
Caspase recruitment domain-containing protein 8

1

13

Small-scale

0.479

High

737566

PGM1
Phosphoglucomutase-1

1

0

Small-scale

0.460

High

872085

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

Small-scale

0.460

High

656075

PSB8
Proteasome subunit beta type-8

1

0

Small-scale

0.458

High

1063109

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.458

High

1073714

SF3A2
Splicing factor 3A subunit 2

1

0

Small-scale

0.458

High

1174166

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

Small-scale

0.458

High

1299050

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.458

High

92290

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.437

High

782460

P2RY2
P2Y purinoceptor 2

1

7

Small-scale

0.437

High

1185434

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

92521

E9PJ24
PHD and ring finger domains 1

1

1

High-throughput

0.407

High

1133021

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.407

High

230075

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.279

Low

1299035

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024