HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	11585840, 33665565
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 81
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		874069 PSMD4_HUMAN (1-364): 0: 530: 100.00		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		474970 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Dm
		547908 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		RS27A_DROME (1-77): 3.39e-36: 121: 57.14
+	Dm
		874041 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		NEDD8_DROME (1-76): 2.21e-34: 113: 93.42
+	Sp
		293402 RPN10_SCHPO (1-245): 5.11e-104: 308: 45.75		RL402_SCHPO (1-76): 6.88e-32: 109: 55.26
+	Sc
		757022 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21