HitPredict

Interactor 1: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Interactor 2: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 25416956, 32296183, 12232792, 21988832, 8900201, 31515488, unassigned1304, 20890311
Identification Methods two hybrid, enzymatic study, protease assay, two hybrid array, two hybrid prey pooling approach, validated two hybrid, x-ray crystallography
Interaction Type direct interaction, protein cleavage, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Peptidase_C14~Peptidase_C14
Common GO terms GO:0002218 - activation of innate immune response
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 16 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 293
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1 293
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024